Taste cues elicit prolonged modulation of feeding behavior in Drosophila

• Authors: Julia U Deere, Columbia University; Anita Devineni, Emory University
• Journal Title: iScience
• Volume: Volume 25, Number 10
• Publisher: Elsevier | 2022-10-21
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.1016/j.isci.2022.105159
• Subjects: Biology, General; Biology, Neuroscience
• Keywords: behavior; Drosophila

Abstract

Taste cues regulate immediate feeding behavior, but their ability to modulate future behavior has been less well studied. Pairing one taste with another can modulate subsequent feeding responses through associative learning, but this requires simultaneous exposure to both stimuli. We investigated whether exposure to one taste modulates future responses to other tastes even when they do not overlap in time. Using Drosophila, we found that brief exposure to sugar enhanced future feeding responses, whereas bitter exposure suppressed them. This modulation relies on neural pathways distinct from those that acutely regulate feeding or mediate learning-dependent changes. Sensory neuron activity was required not only during initial taste exposure but also afterward, suggesting that ongoing sensory activity may maintain experience-dependent changes in downstream circuits. Thus, the brain stores a memory of each taste stimulus after it disappears, enabling animals to integrate information as they sequentially sample different taste cues that signal local food quality.