Striatal Oscillations in Parkinsonian Non-Human Primates

• Authors: Arun Singh, Emory University; Stella Papa, Emory University
• Journal Title: NEUROSCIENCE
• Volume: Volume 449
• Publisher: PERGAMON-ELSEVIER SCIENCE LTD | 2020-11-21, Pages 116-122
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1016/j.neuroscience.2020.09.004
• Subjects: Health Sciences, Medicine and Surgery
• Keywords: Science & Technology; Life Sciences & Biomedicine; Neurosciences; Neurosciences & Neurology; local field potentials; striatal projection neurons; Parkinson's disease; dopamine; non-human primates; MEDIUM SPINY NEURONS; SUBTHALAMIC NUCLEUS; BETA-OSCILLATIONS; PROJECTION NEURONS; ACTIVITY PATTERNS; CEREBRAL-CORTEX; DOPAMINE; MOVEMENT; NETWORK; BRAIN

Abstract

Dopamine loss in Parkinson's disease (PD) is associated with abnormal oscillatory activity in the cortico-basal ganglia network. However, the oscillatory pattern of striatal neurons in PD remains poorly defined. Here, we analyzed the local field potentials in one untreated and five MPTP-treated non-human primates (NHP) with chronic, advanced parkinsonism. Oscillatory activities in the alpha (8–13 Hz) and low-beta (13–20 Hz) frequency bands were found in the striatum similarly to the motor cortex and globus pallidus of the NHP model of PD. Both alpha and low-beta frequency band oscillations of the striatum were highly coherent with the cortical and pallidal oscillations, confirming the presence of abnormal 8–20 Hz oscillatory activity in the cortico-basal ganglia network in parkinsonian NHPs. The reversal of parkinsonism induced by acute levodopa administration was associated with reduced 8–20 Hz oscillations in the striatum. These findings indicate that pathological oscillations at alpha and low-beta bands are also present in the striatum concordant with basal ganglia network changes in the primate model of PD.