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Galter@mgh.harvard.edu and rmedinai@uc.cl
Conceptualization, X.T., R.P.M., M.J.A., R.A.M., and G.A.; Methodology, X.T., R.P.M., and G.A; Validation, X.T.; Formal Analysis, X.T., R.P.M., and G.A.; Investigation, X.T., R.P.M., G.A., M.J.A. and R.A.M.; Cohort study design, supervised and managed the sample collection, T.G.S., C.P.R., A.R. and R.A.M.; Processed samples, revised the paper, T.G.S., C.P.R., J.L., E.P., E.S., A.M., A.R. and R.A.M.; Resources, G.A. and R.A.M.; Writing – Original Draft, X.T. and R.P.M.; Writing – Review & Editing, R.P.M., G.A., M.J.A. and R.A.M.; Visualization, X.T., R.P.M., and G.A.; Project Administration, R.P.M.; Funding Acquisition, G.A. and R.A.M.; Supervision, R.P.M., R.A.M. and G.A.
We would like to thank the laboratory of Prof. Douglas Lauffenburger (Massachusetts Institute of Technology) for the critical evaluation of statistics in this manuscript. We also thank Mark and Lisa Schwartz, Terry and Susan Ragon, and the SAMANA Kay MGH Research Scholars award for their support. G.A. receives funding from the Massachusetts Consortium on Pathogen Readiness (MassCPR), the Gates Global Health Vaccine Accelerator Platform, and the NIH (3R37AI080289-11S1, R01AI146785, U19AI42790-01, U19AI135995-02, U19AI42790-01, P01AI1650721, U01CA260476 - 01, CIVIC75N93019C00052).
We also would like to thank Estefany Poblete, Erick Salinas and Andres Muñoz for their excellent technical and professional expertise during clinical recruitment and sample processing.
Galit Alter is a founder/equity holder in Seroymx Systems and Leyden Labs. GA has served as a scientific advisor for Sanofi Vaccines. GA has collaborative agreements with GSK, Merck, Abbvie, Sanofi, Medicago, BioNtech, Moderna, BMS, Novavax, SK Biosciences, Gilead, and Sanaria. RAM has served as a scientific advisor for Valneva SE.
Work in the Medina laboratory was partially funded by the FONDECYT 1212023 grant from ANID of Chile, the FLUOMICS Consortium (NIH-NIAID grant U19AI135972) and the Center for Research on Influenza Pathogenesis (CRIP), an NIAID Center of Excellence for Influenza Research and Surveillance (CEIRS, contract # HHSN272201400008C).
CPR and JL conducted this work as part of their Postdoctoral grant FONDECYT 3190706 and 3190648, respectively
MJA and ES conducted this work as part of their Ph.D. Thesis, under Programa de Doctorado en Ciencias Biológicas mención Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Cátolica de Chile.
MJA was funded by the ANID Becas/Doctorado Nacional 21212258 scholarship and ES was funded by a scholarship from Vicerrectoría de Investigación de la Escuela de Graduados, Pontificia Universidad Católica de Chile.