Surgery for acromegaly: Indications and goals

• Authors: David P Bray, Emory University; Sai Mannam, Emory University; Rima S Rindler, Mayo Clinic; Joseph W Quillin, Medical City Hospital - Dallas; Nelson Oyesiku, Emory University
• Journal Title: Frontiers in Endocrinology
• Volume: Volume 13
• Publisher: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386525/bin/DataSheet_1.zip | 2022-08-04, Pages 924589-924589
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.3389/fendo.2022.924589
• Subjects: Health Sciences, Pharmacy; Health Sciences, Medicine and Surgery
• Keywords: acromegaly; adenoma; endonasal; endoscopic; pituitary; skull-base; transnasal; Acromegaly; Adenoma; Goals; Growth Hormone-Secreting Pituitary Adenoma; Humans; Pituitary Neoplasms

Abstract

Acromegaly is a disease that occurs secondary to high levels of GH, most often from a hormone-secreting pituitary adenoma, with multisystem adverse effects. Diagnosis includes serum GH and IGF-1 levels, and obtaining an MRI pituitary protocol to assess for a functional pituitary adenoma. Attempted gross total resection of the GH-secreting adenoma is the gold standard in treatment for patients with acromegaly for a goal of biochemical remission. Medical and radiation therapies are available when patients do not achieve biochemical cure after surgical therapy.