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Author Notes:

Kelly C. Goldsmith, kgoldsm@emory.edu; Tel.: +1-404-727-2655

Conceptualization, J.S., K.C.G. Writing—original draft preparation, J.S.; writing—review and editing, J.S., K.C.G. Funding acquisition, J.S., K.C.G. All authors have read and agreed to the published version of the manuscript.

We would like to thank Hunter C. Jonus for her kind and thorough review of the manuscript.

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Subjects:

Research Funding:

This research was funded by Hyundai Hope on Wheels, Young Investigator Grant, grant number 639727 to J.S. and Hyundai Hope on Wheels, Scholars Award, grant to K.C.G.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Oncology
  • neuroblastoma
  • tumor microenvironment
  • yes-associated protein
  • hippo pathway
  • hypoxia
  • angiogenesis
  • extracellular matrix
  • metastasis
  • therapy resistance
  • EPITHELIAL-MESENCHYMAL TRANSITION
  • BREAST-CANCER METASTASIS
  • HIPPO PATHWAY
  • TRANSCRIPTIONAL COACTIVATOR
  • EXTRACELLULAR-MATRIX
  • STEM-CELLS
  • PROMOTER METHYLATION
  • MEDIATES RESISTANCE
  • PRECLINICAL MODELS
  • CONTACT INHIBITION

A New Player in Neuroblastoma: YAP and Its Role in the Neuroblastoma Microenvironment

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Journal Title:

CANCERS

Volume:

Volume 13, Number 18

Publisher:

Type of Work:

Article | Final Publisher PDF

Abstract:

Neuroblastoma is the most common extra-cranial pediatric solid tumor that accounts for more than 15% of childhood cancer-related deaths. High risk neuroblastomas that recur during or after intense multimodal therapy have a <5% chance at a second sustained remission or cure. The solid tumor microenvironment (TME) has been increasingly recognized to play a critical role in cancer progression and resistance to therapy, including in neuroblastoma. The Yes-Associated Protein (YAP) in the Hippo pathway can regulate cancer proliferation, tumor initiation, and therapy response in many cancer types and as such, its role in the TME has gained interest. In this review, we focus on YAP and its role in neuroblastoma and further describe its demonstrated and potential effects on the neuroblastoma TME. We also discuss the therapeutic strategies for inhibiting YAP in neuroblastoma.

Copyright information:

© 2021 by the authors.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/rdf).
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