Editorial: Environmental Effect on Neuroinflammation and Neurodegeneration

• Authors: Monica Renee Langley, Mayo Clinic, Rochester; Srikant Rangaraju, Emory University; Adwitia Dey, Harvard Medical School; Souvarish Sarkar, Harvard Medical School
• Journal Title: FRONTIERS IN CELLULAR NEUROSCIENCE
• Volume: Volume 16
• Publisher: FRONTIERS MEDIA SA | 2022-06-21, Pages 935190-935190
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.3389/fncel.2022.935190
• Subjects: Health Sciences, Pathology; Health Sciences, Rehabilitation and Therapy
• Keywords: Science & Technology; Life Sciences & Biomedicine; Neurosciences; Neurosciences & Neurology; neuroinflammation; neurodegeneration; genetic; GWAS; gene-environment interactions

Abstract

Neurodegenerative disorders like Parkinson's disease and Alzheimer's disease, among others, are characterized by the loss of a specific subset of neurons and glial activation. Genome-wide associated studies (GWAS) have identified various genetical risk factors, and environmental risk factors have been found through epidemiological studies. For example, metals, diet, occupational exposure to pesticides, and pollution, among others, have been shown to play a key role in the manifestation of neurodegeneration and neuroinflammation. Furthermore, interactions between genetic and environmental factors play a key role in these disease etiologies.