Newly codified glial neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: Angiocentric glioma, pilomyxoid astrocytoma and pituicytoma

• Authors: Daniel Brat, Emory University; Bernd W Scheithauer, Mayo Clinic, Rochester; Gregory N Fuller, The University of Texas M. D. anderson Cancer Center; Tarik Tihan, The University of California at San Francisco
• Journal Title: BRAIN PATHOLOGY
• Volume: Volume 17, Number 3
• Publisher: WILEY | 2007-07-01, Pages 319-324
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.1111/j.1750-3639.2007.00082.x
• Subjects: Health Sciences, Pathology; Health Sciences, Medicine and Surgery
• Keywords: Science & Technology; Life Sciences & Biomedicine; Clinical Neurology; Neurosciences; Pathology; Neurosciences & Neurology; PILOCYTIC ASTROCYTOMA; HUMAN NEUROHYPOPHYSIS; CELLULAR-ELEMENTS; FEATURES; PATIENT

Abstract

The 4th edition of the WHO Classification of Tumours of the Nervous System (WHO 2007) introduces changes that reflect both the recognition of new brain tumour types and a better understanding of neoplastic behavior. Three new tumours, angiocentric glioma (AG), pilomyxoid astrocytoma (PMA), and pituicytoma are added to the section on gliomas. AG is a slowly growing cerebral tumour that typically presents with seizures in children and young adults. It is characterized by monomorphous, bipolar tumour cells with a striking perivascular growth pattern. Although the 'cell of origin' of AG is not clear, ultrastructural evidence points to an ependymal derivation. Typically, AG can be cured by total resection, and is designated WHO grade I. PMA is a solid, circumscribed tumour occurring mainly in the hypothalamic region of young children. It is composed of a monomorphous population of bipolar tumour cells within a rich myxoid background, with a conspicuous anglocentric arrangement. While PMA is considered a more aggressive variant of pilocytic astrocytoma, this relationship awaits further clarification. The PMA has been designated WHO grade II. The pituicytoma, involves the posterior pituitary and/or its stalk and affects adults. It is solid in architecture, composed of spindle cells and presumably derived from pituicytes. Pituicytomas are indolent tumours, and are designated WHO grade I. © 2007 The Authors.