Cost-effectiveness of infant respiratory syncytial virus preventive interventions in Mali: A modeling study to inform policy and investment decisions

• Authors: Evan Orenstein, Emory University; Lauren Orenstein, Emory University; RS Laufer, Univ Maryland; AJ Driscoll, Univ Maryland; R Baral, PATH; AG Buchwald, Colorado Sch Publ Hlth; JD Campbell, Univ Maryland; F Coulibaly, Minist Sante; F Diallo, Minist Sante; M Doumbia, Minist Sante; AP Galvani, Yale Sch Publ Hlth; FC Haidara, Minist Sante; KL Kotloff, Univ Maryland; AM Keita, Minist Sante; KM Neuzil, Univ Maryland; C Pecenka, PATH; S Sow, Minist Sante; MD Tapia, Univ Maryland; JR Ortiz, Univ Maryland; MC Fitzpatrick, Univ Maryland
• Journal Title: VACCINE
• Volume: Volume 39, Number 35
• Publisher: ELSEVIER SCI LTD | 2021-08-05, Pages 5037-5045
• Type of Work: Article
• Publisher DOI: http://doi.org/10.1016/j.vaccine.2021.06.086
• Keywords: Science & Technology; Life Sciences & Biomedicine; Immunology; Medicine, Research & Experimental; Research & Experimental Medicine; Global Health; Vaccine; Pediatric; Respiratory Syncytial Virus; Pneumonia; Prevention; MIDDLE-INCOME COUNTRIES; EFFECTIVENESS THRESHOLDS; DISEASE; BLIND

Abstract

Importance: Low- and middle-income countries have a high burden of respiratory syncytial virus lower respiratory tract infections. A monoclonal antibody administered monthly is licensed to prevent these infections, but it is cost-prohibitive for most low- and middle-income countries. Long-acting monoclonal antibodies and maternal vaccines against respiratory syncytial virus are under development. Objective: We estimated the likelihood of respiratory syncytial virus preventive interventions (current monoclonal antibody, long-acting monoclonal antibody, and maternal vaccine) being cost-effective in Mali. Design: We modeled age-specific and season-specific risks of respiratory syncytial virus lower respiratory tract infections within monthly cohorts of infants from birth to six months. We parameterized with respiratory syncytial virus data from Malian cohort studies, as well as product efficacy from clinical trials. Integrating parameter uncertainty, we simulated health and economic outcomes for status quo without prevention, intra-seasonal monthly administration of licensed monoclonal antibody, pre-seasonal birth dose administration of a long-acting monoclonal antibody, and maternal vaccination. We then calculated the incremental cost-effectiveness ratio of each intervention compared to status quo from the perspectives of the government, donor, and society. Results: At a price of $3 per dose and from the societal perspective, current monoclonal antibody, long-acting monoclonal antibody, and maternal vaccine would have incremental cost-effectiveness ratios of $4280 (95% CI $1892 to $122,434), $1656 (95% CI $734 to $9091), and $8020 (95% CI $3501 to $47,047) per disability-adjusted life-year averted, respectively. Conclusions and Relevance: In Mali, long-acting monoclonal antibody is likely to be cost-effective from both the government and donor perspectives at $3 per dose. Maternal vaccine would need higher efficacy over that measured by a recent trial in order to be considered cost-effective.