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Author Notes:

Audrey J. Gaskins, Sc.D., Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, CNR 3017, Atlanta, GA 30322. Email: audrey.jane.gaskins@emory.edu

The authors acknowledge the members of the clinical and administrative staff at Reproductive Biology Associates for their support. For additional aid in completing chart review, the authors thank Hannah Marcovitch, Alexandrea Ramsey, Sydney Archer, and Deandrea Ellis. The authors also thank Dr. Michael Heard for financial support.

J.X. has nothing to disclose. H.S.H. has nothing to disclose. S.M.C. has nothing to disclose. Z.P.N. is a member of the Origio/Cooper-Surgical Scientific Advisory Board a stock owner of Prelude Fertility. D.B.S. is a stock owner of Prelude Fertility. J.B.S. has nothing to disclose. A.J.G. has nothing to disclose.

A.J.G. was supported by a career development grant, R00ES026648, from the National Institute of Environmental Health Sciences. REDCap support was provided by UL1 TR000424 at Emory University. The funding sources had no involvement in the study design, collection, analysis, or interpretation of the data; in the writing of the report; and in the decision to submit the article for publication.



  • Donor oocyte
  • assisted reproductive technology
  • birthweight
  • body mass index
  • fertility
  • gestational age
  • in vitro fertilization
  • live birth
  • pregnancy

The effects of oocyte donor and recipient body mass index on live birth rates and pregnancy outcomes following assisted reproduction


Journal Title:

F and S Reports


Volume 2, Number 1


, Pages 58-66

Type of Work:

Article | Final Publisher PDF


Objective: To investigate the effects of oocyte donor and recipient body mass index (BMI) on outcomes of vitrified donor oocyte assisted reproductive technology (ART). Design: Retrospective cohort study. Setting: Private fertility center. Patient(s): A total of 338 oocyte donors and 932 recipients who underwent 1,651 embryo transfer cycles in 2008–2015. Intervention(s): Multivariable log binomial regression models with cluster-weighted generalized estimating equations were used to estimate the adjusted risk ratios. Main Outcome Measure(s): Live birth, defined as the delivery of at least one live-born infant, including all embryo transfer cycles. Secondary outcomes included birth weight and gestational length only among singleton live births. Results: The mean ± SD body mass indexes (BMIs) of donors and recipients were 22.6 ± 2.5 kg/m2 and 24.6 ± 4.8 kg/m2, respectively. There were no significant associations between donor BMI and probability of live birth. Recipients with BMI ≥35 kg/m2 had a significantly higher probability of live birth compared with normal-weight recipients. Among singleton live births, recipients with BMI <18.5 kg/m2 had a lower risk whereas women with BMI ≥35 kg/m2 had a higher risk of delivery in an earlier gestational week compared with normal weight women. Recipients with a BMI ≥35 kg/m2 also had a higher risk of having a low birth weight infant compared with normal-weight women. Conclusions: In the setting of vitrified donor oocyte ART, recipient BMI was positively associated with probability of live birth but negatively associated with gestational length and birth weight among singleton births.

Copyright information:

© 2020 The Author(s)

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/rdf).
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