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Author Notes:

E. N. Kersh, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, MS H-23-3, Atlanta, GA 30329. Email: ekersh@cdc.gov

The authors thank the members of the Centers for Disease Control and Prevention (CDC) Sexually Transmitted Disease Laboratory Group; the external experts who developed or reviewed the key questions or supported the systematic literature reviews; and our colleagues Drs Ina Park and Lara Pereira for insightful review of this manuscript.

The authors: No reported conflicts of interest. Both authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest.


Research Funding:

This article appears as part of the supplement National Coalition of STD Directors, sponsored by the CDC.


  • Science & Technology
  • Life Sciences & Biomedicine
  • Immunology
  • Infectious Diseases
  • Microbiology
  • syphilis diagnostics
  • Treponema pallidum direct detection
  • serology
  • systematic review

Evidence Review for Centers for Disease Control and Prevention Guidance Development on Laboratory Testing to Detect Treponema pallidum Infection (Syphilis)


Journal Title:



Volume 71, Number Suppl 1


, Pages S1-S3

Type of Work:

Article | Final Publisher PDF


The articles in this supplement address key questions on syphilis diagnostics, provide reference tables of test performances, and discuss optimal specimens and knowledge gaps. Laboratory-developed genetic direct detection tests could be most useful at the point of care and add to the currently available serologic methods of nontreponemal and treponemal tests.

Copyright information:

Published by Oxford University Press for the Infectious Diseases Society of America 2020.

This is an Open Access work distributed under the terms of the Creative Commons Universal : Public Domain Dedication License (https://creativecommons.org/publicdomain/zero/1.0/rdf).
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