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Author Notes:

Laren Narapareddy, Nell Hodgson Woodruff School of Nursing, Emory University, 1520 Clifton Road, Atlanta, GA 30322. Email: laren.narapareddy@emory.edu

We thank Dr. Alvaro Hernandez and the staff of the Roy J. Carver Biotechnology Center at the University of Illinois in Urbana‐Champaign for library preparation and sequencing. We are indebted to Aubrey Sills, Donna Layne‐Colon and the animal care staff at Southwest National Primate Research Center and the University of Texas Health Science Center at San Antonio Barshop Center for Longevity and Aging. We also thank Dr. William E. Gundling (Christian Brothers University) for his assistance and guidance with ensuring data availability through the appropriate public data repositories. The authors also thank Dr. Linda Scott (University of Wisconsin‐Madison) for her overall support and constructive comments on earlier versions of this manuscript. Adam Mackintosh provided artistic support in the creation of the graphical abstract. Adelaide Caledonia Goehl continues to elucidate mechanisms underlying maternal investment. All research described herein was conducted under appropriate animal care and use committee guidelines and permits. Funding was provided in part by the Robert Wood Johnson Foundation Future of Nursing Scholars program (Riesche [currently Narapareddy]) and by the National Institutes of Health (R01DK077639, Tardif and R01HD076018, Rutherford).

The authors declare that there are no conflict of interests.

Subjects:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Zoology
  • developmental programming
  • epigenetics
  • maternal metabolism
  • non-human primate
  • obesity
  • NONHUMAN PRIMATE
  • CORD BLOOD
  • EPIGENETICS
  • GROWTH
  • CHIMERISM
  • MODEL

Maternal weight affects placental DNA methylation of genes involved in metabolic pathways in the common marmoset monkey (Callithrix jacchus)

Tools:

Journal Title:

AMERICAN JOURNAL OF PRIMATOLOGY

Volume:

Volume 82, Number 3

Publisher:

, Pages e23101-e23101

Type of Work:

Article | Final Publisher PDF

Abstract:

Accumulating evidence suggests that dysregulation of placental DNA methylation (DNAm) is a mechanism linking maternal weight during pregnancy to metabolic programming outcomes. The common marmoset, Callithrix jaccus, is a platyrrhine primate species that has provided much insight into studies of the primate placenta, maternal condition, and metabolic programming, yet the relationships between maternal weight and placental DNAm are unknown. Here, we report genome-wide DNAm from term marmoset placentas using reduced representation bisulfite sequencing. We identified 74 genes whose DNAm pattern is associated with maternal weight during gestation. These genes are predominantly involved in energy metabolism and homeostasis, including the regulation of glycolytic and lipid metabolic processes pathways.

Copyright information:

© 2020 The Authors. American Journal of Primatology published by Wiley Periodicals, Inc.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/rdf).
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