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Author Notes:

Lori A. Devlin, Email: lori.devlinphinney@louisville.edu

All authors (LAD, LWY, WKK, EMW, AC, SLM, TW, HEJ, BBP, LSW, ALS, AGM, and JMD) critically reviewed the paper outline, participated in drafting the initial paper, critically reviewed subsequent paper drafts, and approved the submitted version. All authors agree to be accountable for all aspects of the work.

The authors thank Kathryn Adams and Andrew A. Bremer from the Eunice Kennedy Shriver National Institute of Child Health and Human Development for reviewing paper drafts and providing insightful edits. The authors also wish to acknowledge the role of BioCentric staff in supporting the development of this paper, including preparing an outline and paper draft based on author presentations at the NIH HEAL Initiative℠ workshop—Toward the Use of Buprenorphine in Infants: Scientific and Practical Considerations.

These authors contributed equally: Lori A. Devlin, Leslie W. Young.

The authors declare no competing interests.

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Research Funding:

LAD reports funding from NIH HEAL for ACT NOW CE and ESC (U24 HD095254 and U2C OD023375); LWY reports funding from NIH HEAL for ACT NOW CE and ESC (U24 HD095254 and U2C OD023375), HBCD Phase I Planning Grant (1R34DA050283-01), and MOTHER DYAD (R011DA047867-01); WKK reports Thomas Jefferson University receiving research and consulting grants from Chiesi USA, Inc.; EMW reports no conflicts of interest; SLM reports funding from NIH HEAL for HBCD Phase 1 (R34 DA050268) and ACT NOW OBOE (PL1 HD101059/RL1 HD104254); TW reports the University of Cincinnati receiving research grant funding (UG1DA013732) from the National Institute on Drug Abuse, National Drug Abuse Treatment Clinical Trials Network, NIH; HEJ reports no conflicts of interest; LSW reports funding from HBCD Phase I Planning Grant (R34DA050266); ALS reports NIH HEAL research funding (R01DA015778-5); AGM is an employee of the Emmes Company which receives NIH HEAL funds through their support of the National Drug Abuse Treatment Clinical Trials Network (contract 75N95019D00013); JMD reports receiving funding from the March of Dimes to examine novel agents for preventing or treating NAS and receiving funding from NIDA, NICHD, and the Charles Hood Foundation for various studies of NAS. Funding for the role of BioCentric in supporting the development of this manuscript was provided by the Pregnancy and Perinatology Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

Keywords:

  • Analgesics, Opioid
  • Buprenorphine
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Methadone
  • Neonatal Abstinence Syndrome
  • Opioid-Related Disorders
  • Pregnancy

Neonatal opioid withdrawal syndrome: a review of the science and a look toward the use of buprenorphine for affected infants

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Journal Title:

Journal of Perinatology

Volume:

Volume 42, Number 3

Publisher:

, Pages 300-306

Type of Work:

Article | Final Publisher PDF

Abstract:

Neonates born to mothers taking opioids during pregnancy are at risk for neonatal opioid withdrawal syndrome (NOWS), for which there is no recognized standard approach to care. Nonpharmacologic treatment is typically used as a first-line approach for management, and pharmacologic treatment is added when clinical signs are not responding to nonpharmacologic measures alone. Although morphine and methadone are the most commonly used pharmacotherapies for NOWS, buprenorphine has emerged as a treatment option based on its pharmacologic profile and results from initial single site clinical trials. The objective of this report is to provide an overview of NOWS including a summary of ongoing work in the field and to review the state of the science, knowledge gaps, and practical considerations specific to the use of buprenorphine for the treatment of NOWS as discussed by a panel of experts during a virtual workshop hosted by the National Institutes of Health.

Copyright information:

© The Author(s), under exclusive licence to Springer Nature America, Inc. 2021

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