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Lisa A. Carey, Email: lisa_carey@med.unc.edu
L.A.C., D.L., K.P., A.B., V.D., F.D., J.R.D., C.F., G.W., H.S.R., S.A.H., K.K., J.O., S.L., L.G., M.P., Y.Z., S.P., and J.C. contributed to data collection and interpretation. Y.Z., R.D., and S.P. contributed to analysis design, data analysis, and interpretation. All authors contributed to the writing and/or review of the final manuscript.
We thank the dedicated clinical trial investigators and their devoted team members participating in the ASCENT trial. We thank Loretta M. Itri, Martin S. Olivo, and Quan Hong, PhD for their previous work in data analysis of this subgroup. Medical writing and editorial assistance were provided by Colleen Elliott, PhD, and Yao Bian, PhD, at Team 9 Science, and were funded by Gilead Sciences, Inc
L.A.C. reports research funding from Sanofi, Novartis, Genentech/Roche, and GSK; spouse serves on the board of Falcon Therapeutics. D.L. reports consultancy/advisory roles with Novartis, MSD, and Roche. K.P. reports research funding from Sanofi; consultancy/advisory roles with AstraZeneca, Eli Lilly, Gilead, Medscape, Novartis, Pfizer, Pierre Fabre, Roche, Roularta, and Vifor Pharma; honoraria from Eli Lilly, McCann Health, Mundi Pharma, MSD, Novartis, Pfizer, and Roche; travel/accommodations/expenses from AstraZeneca, Novartis, Pharmamar, Roche, and Pfizer. A.B. research funding from Genentech, Novartis, Pfizer, Merck, Sanofi, Radius Health, Immunomedics, and Biotheranostics; personal fees from Pfizer, Novartis, Genentech, Merck, Radius Health, Immunomedics, Taiho, Sanofi, Daiichi Sankyo/AstraZeneca, Puma, Phillips, Eli Lilly, and Foundation Medicine. V.D. reports travel/accommodations/expenses from Genentech/Roche, Novartis, Eli Lilly, Pfizer, AstraZeneca, and Daiichi Sankyo; honoraria from AbbVie, AstraZeneca, Daiichi Sankyo, Eisai, Eli Lilly, Genentech/Roche, MSD, Novartis, Pfizer, and Seattle Genetics. J.R.D. reports research funding from Takeda, Immunomedics, Merck, Bristol Myers Squibb, OncoMed, Rexahn, OnKure, and AstraZeneca; personal fees from Immunomedics. G.W. reports research funding from Daiichi-Sankyo, Immunomedics, Sermonix, Eli Lilly, OBI Pharma, Seattle Genetics, Eisai, Pfizer, Tesaro, and Pharmacyclics. HSR reports research funding from AstraZeneca, Pfizer, Novartis, Eli Lilly, Genentech, Immunomedics, MacroGenics, OBI, Merck, Eisai, Immunomedics, Daiichi Sankyo, Seattle Genetics, Odonate, and Sermonix; travel/accommodations/expenses from Daiichi Sankyo, Mylan, Pfizer, Merck, AstraZeneca, Novartis, and MacroGenics; honoraria from Mylan, Samsung, and Puma. SAH reports research funding from Ambrx, Amgen, Arvinas, Bayer, Daiichi Sankyo, Genentech/Roche, GSK, Immunomedics, Eli Lilly, Macrogenics, Novartis, Pfizer, OBI Pharma, Pieris, PUMA, Phoenix Molecular Designs, Radius, Sanofi, Seattle Genetics, and Dignitana; stock from NK Max; stock (spouse) from ROMTech and Ideal Implant. K.K. reports research funding from Immunomedics, Novartis, Incyte, Genentech, Eli Lilly, Pfizer, Calithera, Acetylon, Seattle Genetics, Amgen, Zeno, and CytomX Therapeutics; advisory role with Immunomedics, AstraZeneca, and Genentech; consulting fees from Immunomedics, Pfizer, Eisai, Eli Lilly, Novartis, Amgen, and AstraZeneca, Genentech, Merck, Seattle Genetics, Cyclacel, and OncoSec; honoraria from Eli Lilly; travel/accommodations/expenses from Eli Lilly, Pfizer, and AstraZeneca; employment (spouse) with Array Biopharma, Pfizer, and Grail. J.O. reports consultancy/advisory roles with AbbVie, Agendia, Amgen, Aptitude Health, AstraZeneca, Bristol Myers Squibb, Celgene, Eisai, G1 Therapeutics, Genentech/Roche, Immunomedics, Ipsen, Eli Lilly, Merck, Myriad, Novartis, Odonate, Pfizer, Puma, Prime Oncology, Seattle Genetics, and Syndax; honoraria from Gilead. S.L. reports research funding from Immunomedics and Vifor; consultancy/advisory roles with AbbVie, Amgen, AstraZeneca, Bayer, Bristol Myers Squibb, Celgene, Daiichi Sankyo, Eli Lilly, EirGenix, GSK, Merck, Novartis, Pfizer, Pierre Fabre, Prime/Medscape, Puma, Roche, Samsung, Seattle Genetics; speaker’s bureau for Chugai. L.G. reports personal fees from ADC Therapeutics, Amgen, AstraZeneca, Celgene, Eli Lilly, Roche, Forty Seven (CD47), G1Therapeutics, Genenta, Genentech, Genomic Health, Daiichi Sankyo, Sandoz, Menarini Ricerche, Merck, Metis Precision Medicine, Novartis, Odonate Therapeutics, Oncolytics, Onkaido, Pfizer, Revolution Medicine, Sanofi, Seattle Genetics, Synaffix, Synthon, Tahio, and ZymeWorks; research funding from Zymworks; intellectual property rights/patent holder in conjunction with Roche. M.P. reports consultancy/advisory roles with Camel-IDS, Debiopharm, Immunomedics, Immutep, Menarini, Odonate, Genentech/Roche, Seattle Genetics, and Oncolytics; speaker roles with AstraZeneca, Eli Lilly, MSD, Novartis, Pfizer, and Genentech/Roche; research funding from AstraZeneca, Immunomedics, Eli Lilly, Menarini, Novartis, Pfizer, Radius, Genentech/Roche, Servier, and Synthon. Y.Z., R.D., and S.P. report employment with Gilead and may own stock or stock options. J.C. reports consultancy/advisory roles with Roche, Celgene, Cellestia, AstraZeneca, Biothera Pharmaceutical, Merus, Seattle Genetics, Daiichi Sankyo, Erytech, Athenex, Polyphor, Eli Lilly, Servier, Merck, GSK, Leuko, Bioasis, and Clovis Oncology; speaker’s bureau for Roche, Novartis, Celgene, Eisai, Pfizer, Samsung, Eli Lilly, Merck, and Daiichi Sankyo; research funding from Roche, Ariad, AstraZeneca, Baxalta GMBH/Servier Affaires, Bayer, Eisai, Roche, Guardant Health, Merck, Pfizer, Piqur Therapeutics, Puma, Queen Mary University of London; stock in MedSIR. F.D. and C.F. have no disclosures to report.
This study was sponsored by Gilead Sciences, Inc. We thank the patients and their caregivers for helping us realize the possibilities of this research.
© The Author(s) 2022