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Judith L Fridovich-Keil, Department of Human Genetics, Emory University School of Medicine, Rm. 325.2 Whitehead Bldg., 615 Michael St, Atlanta, GA 30322 TEL 404-727-3924, FAX 404-727-3949. Email: jfridov@emory.edu
Shauna Rasmussen helped to design and interpret experiments, performed or oversaw the majority of animal work performed, and participated in writing and editing of the manuscript. Jenna Daenzer helped to design and interpret experiments, performed or oversaw the majority of biochemical and metabolic work performed, and participated in writing and editing of the manuscript. Judith Fridovich-Keil coordinated the activities of all collaborators, helped to design and interpret experiments, and did most of the writing and editing of the manuscript.
We are grateful to numerous colleagues for their contributions to this project. We specifically thank Dr. Michael Castle for his priceless guidance on everything AAV, Drs. Oskar Laur and Xinping Huang and their colleagues in the Emory Integrated Cores for generating the AAV vector and viral stock used in this study, and Dr. Lyra Griffiths, also from the Emory Integrated Cores, for performing the quantitative PCR required to calculate viral genome copy number in tissue samples. We also thank all members of the Fridovich-Keil lab for constant support, and the many professionals working in the Emory Division of Animal Resources and the Emory IACUC without whom this work could not have been conducted.
All of the authors declare that they have no competing interests.
This work was supported in part by grants from the National Institutes of Health R01DK107900 and R21HD092785 (both to JLFK), and in part by the Emory Integrated Genomics Core (EIGC), which is subsidized by the Emory University School of Medicine and is one of the Emory Integrated Core Facilities.