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Author Notes:

Nicole R. Bush, nicole.bush@ucsf.edu

NB, KL, CK, SS, and FT played a role in funding acquisition for the project supporting this manuscript. FT, JG, NB, and KL contributed to conception and design of the cohort study from which the data were drawn. FT was primarily responsible for project administration and supervision of data acquisition and curation, with support for data curation from NB and KL. SA and NB devised the manuscript study question. SA and ES designed the analytic approach for the study, with oversight by NB and wrote the first draft of the manuscript. ES performed the statistical analyses. LR and NB wrote sections of the manuscript. NB supervised the writing. All authors contributed to the interpretation of results, manuscript revision, and read and approved the submitted version.

We are grateful for the participation of families enrolled in the CANDLE cohort, as well as the dedication of CANDLE research staff and investigators.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Subject:

Research Funding:

The ECHO PATHWAYS consortium was funded by the NIH (grants 1UG3OD023271-01 and 4UH3OD023271-03). The CANDLE study was also funded by the Urban Child Institute and the NIH (R01 HL109977). The present study was also affiliated with support from the CANDLE Developmental Origins of Health and Disease study (CIHR award number MWG-146331). NB is the Lisa and John Pritzker Distinguished Professor of Developmental and Behavioral Health and receives support from the Lisa Stone Pritzker Family Foundation and the Tauber Family Foundation.

Keywords:

  • prenatal stress
  • executive functioning
  • externalizing behavior
  • parenting
  • child psychopathology

Intergenerational Transmission of Effects of Women's Stressors During Pregnancy: Child Psychopathology and the Protective Role of Parenting

Tools:

Journal Title:

Frontiers in Psychiatry

Volume:

Volume 13

Publisher:

Type of Work:

Article | Final Publisher PDF

Abstract:

Experiences of stress and adversity, such as intimate partner violence, confer risk for psychiatric problems across the life span. The effects of these risks are disproportionately borne by women and their offspring—particularly those from communities of color. The prenatal period is an especially vulnerable period of fetal development, during which time women's experiences of stress can have long-lasting implications for offspring mental health. Importantly, there is a lack of focus on women's capacity for resilience and potential postnatal protective factors that might mitigate these intergenerational risks and inform intervention efforts. The present study examined intergenerational associations between women's prenatal stressors and child executive functioning and externalizing problems, testing maternal parenting quality and child sex as moderators, using a large, prospective, sociodemographically diverse cohort.

Copyright information:

© 2022 Ahmad, Shih, LeWinn, Rivera, Graff, Mason, Karr, Sathyanarayana, Tylavsky and Bush.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/rdf).
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