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Wen‐xia Tian, Email: wenxiatian@126.com
WT, QW, and GFG initiated and coordinated the project. QW designed the experiments. SN and BB performed the SPR analysis, and SN. YJ, and QC conducted the flow cytometry assay. SN and AZ performed the pseudovirus infection assay. SN, BB, CQ, and YZ prepared the complexes of GX/P2V/2017 RBD‐hACE2 and GD/1/2019 RBD‐hACE2. JW and H‐WW prepared the samples and collected the structural data. JW and JQ solved the cryo‐EM structures. SN, LW, PH, QW, and GFG analyzed the data. SN, PD, QW, and GFG wrote the manuscript.
We are grateful to Zheng Fan (Institute of Microbiology, Chinese Academy of Sciences (CAS)) for their technical support of SPR analysis. We thank Jianlin Lei, Xiaomin Li at Tsinghua University for data collection. We thank the Tsinghua University Branch of the China National Center for Protein Sciences (Beijing) for providing the cryo‐EM facility support and the computational facility support on the cluster of Bio‐Computing Platform.
The authors declare that they have no conflict of interest.
This work was supported by the Ministry of Science and Technology of the People’s Republic of China (2020YFC0840800 and 2020YFC0845900), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB29010202), the intramural special grant for SARS‐CoV‐2 research from the Chinese Academy of Sciences, and the National Natural Science Foundation of China (81922044). Q.W. is supported by the Youth Innovation Promotion Association CAS (2018119). G.F.G is supported by the Yanqi Lake Meeting organized by the Academic Divisions of CAS.
© 2021 The Authors