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Author Notes:

Benjamin C Tendler, benjamin.tendler@ndcn.ox.ac.uk

Karla L Miller, karla.miller@ndcn.ox.ac.uk

See publication for Author Contributions

No competing interests declared.

Research Funding:

This paper was supported by the following grants:

Wellcome Trust 202788/Z/16/Z to Benjamin C Tendler, Ricarda AL Menke, Jeroen Mollink, Adele Smart, Karla L Miller.

Wellcome Trust to Taylor Hanayik, Duncan Mortimer.

Medical Research Council, Alzheimer's UK and NIHR Oxford Biomedical Research Centre to Olaf Ansorge.

Alfred Benzon's Foundation to Mads F Bertelsen.

Biotechnology and Biological Sciences Research Council BB/N019814/1 to Katherine L Bryant, Rogier B Mars.

Medical Research Council MR/K02213X/1 to Sean Foxley, Menuka Pallebage-Gamarallage

Netherlands Organization for Scientific Research NWO VIDI-452-16-015 to Martijn P van den Heuvel.

Netherlands Organization for Scientific Research NWO ALW-179 to Martijn P van den Heuvel

European Research Council ERC-COG 101001062 to Martijn P van den Heuvel.

Engineering and Physical Sciences Research Council EP/L016052/1 to Amy FD Howard, Istvan N Huszar.

Medical Research Council MR/L009013/1 to Istvan N Huszar, Amy FD Howard, Saad Jbabdi.

Cancer Research UK C5255/A15935 to Alexandre A Khrapitchev.

National Research Foundation of South Africa to Paul R Manger.

Medical Research Council MR/K01014X/1 to Ricarda AL Menke.

Biotechnology and Biological Sciences Research Council BB/M011224/1 to Lea Roumazeilles.

IDEXLYON IMPULSION 2020 IDEX/IMP/2020/14 to Jerome Sallet.

Labex CORTEX (Université de Lyon) ANR-11-LABX-0042 to Jerome Sallet.

NIHR Oxford Biomedical Research Centre to Connor Scott.

Motor Neurone Disease Association to Martin R Turner.

China Scholarship Council to Chaoyue Wang.

Wellcome Trust 221933/Z/20/Z to Saad Jbabdi.

Wellcome Trust 215573/Z/19/Z to Saad Jbabdi.

Netherlands Organization for Scientific Research NWO 452-13-015 to Rogier B Mars.


  • MRI
  • Microscopy
  • comparative neuroanatomy
  • data resource
  • human
  • human neuroanatomy
  • neuropathology
  • neuroscience
  • post-mortem
  • Access to Information
  • Animals
  • Autopsy
  • Brain
  • Humans
  • Magnetic Resonance Imaging
  • Neuroimaging

The Digital Brain Bank, an open access platform for post-mortem datasets

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Journal Title:



Volume 11


Type of Work:

Article | Final Publisher PDF


Post-mortem MRI provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy, and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank), a data release platform providing open access to curated, multimodal post-mortem neuroimaging datasets. Datasets span three themes-Digital Neuroanatomist: datasets for detailed neuroanatomical investigations; Digital Brain Zoo: datasets for comparative neuroanatomy; Digital Pathologist: datasets for neuropathology investigations. The first Digital Brain Bank release includes twenty one distinctive whole-brain diffusion MRI datasets for structural connectivity investigations, alongside microscopy and complementary MRI modalities. This includes one of the highest-resolution whole-brain human diffusion MRI datasets ever acquired, whole-brain diffusion MRI in fourteen non-human primate species, and one of the largest post-mortem whole-brain cohort imaging studies in neurodegeneration. The Digital Brain Bank is the culmination of our lab’s investment into post-mortem MRI methodology and MRI-microscopy analysis techniques. This manuscript provides a detailed overview of our work with post-mortem imaging to date, including the development of diffusion MRI methods to image large post-mortem samples, including whole, human brains. Taken together, the Digital Brain Bank provides cross-scale, cross-species datasets facilitating the incorporation of post-mortem data into neuroimaging studies.

Copyright information:

© 2022, Tendler et al

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/rdf).
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