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Author Notes:


Conceptualization, V.S.; Funding, V.S., C.L., M.M.; Original Draft, A.T., L.N., V.S.; Experiments: A.T., L.N., G.K.; Data Curation and Analysis, A.T., G.K., B.H., M.T., C.L.; Revision, V.S., H.B.H.; Resources, C.L., H.B.H., M.M., V.S.

Author V.S. is a Guest Editor on the Advanced Manufacturing of Tissue Constructs Special Issue published in iScience. Author M.M. discloses that (i) he is a co-founder and director of the Academic Parity Movement (www.paritymovement.org), a non-profit organization dedicated to addressing academic discrimination, violence and incivility; (ii) he is a Founding Partner at Partners in Global Wound Care (PGWC); and (iii) he receives royalties/honoraria for his published books, plenary lectures, and licensed patents.


Research Funding:

The authors acknowledge the support from the National Institutes of Health (R00 HL127295 and R01 MH126195 to V.S., and NIAID R01 AI153071 to C.L.), National Science Foundation (NSF CAREER Award to V.S.), and Emory University Dean’s Imagine, Innovate and Impact (I3) Research Award (to V.S.). Research reported in this publication was supported in part by the Emory University Integrated Cellular Imaging (ICI) Core and Children’s Healthcare of Atlanta (CHOA). M.M. gratefully acknowledges financial support from the U.S. National Institute of Diabetes and Digestive and Kidney Diseases (grant DK131417).


  • Biomaterials
  • Nanoparticles
  • Tissue engineering

3D bioprinting of nanoparticle-laden hydrogel scaffolds with enhanced antibacterial and imaging properties


Journal Title:



Volume 25, Number 9


, Pages 104947-104947

Type of Work:

Article | Final Publisher PDF


Biomaterial-associated microbial contaminations in biologically conducive three-dimensional (3D) tissue-engineered constructs have significantly limited the clinical applications of scaffold systems. To prevent such infections, antimicrobial biomaterials are rapidly evolving. Yet, the use of such materials in bioprinting-based approaches of scaffold fabrication has not been examined. This study introduces a new generation of bacteriostatic gelatin methacryloyl (GelMA)-based bioinks, incorporated with varying doses of antibacterial superparamagnetic iron oxide nanoparticles (SPIONs). The SPION-laden GelMA scaffolds showed significant resistance against the Staphylococcus aureus growth, while providing a contrast in magnetic resonance imaging. We simulated the bacterial contamination of cellular 3D GelMA scaffolds in vitro and demonstrated the significant effect of functionalized scaffolds in inhibiting bacterial growth, while maintaining cell viability and growth. Together, these results present a new promising class of functionalized bioinks to 3D bioprint tissue-engineered scaffold with markedly enhanced properties for the use in a variety of in vitro and clinical applications.

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© 2022 The Author(s)

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/rdf).
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