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Author Notes:

Paul C. VanVeldhuisen, PhD, The Emmes Company, LLC, 401 N. Washington Street, Suite 700, Rockville, MD 20850; Telephone: 301-251-1161; Fax: 301-251-1355; Email: score2@emmes.com

Andrew Hendrick, MD: Conceptualization, investigation, review and editing Paul C. VanVeldhuisen, PhD: Data curation, formal analysis, funding acquisition, investigation, methodology, project administration, resources, software, supervision, validation, original draft, review, editing Ingrid U. Scott, MD, MPH: funding acquisition, methodology, project administration, resources, supervision, original draft, review, editing Jacquie King, MS: data curation, formal analysis, validation, original draft, review, editing Barbara A. Blodi, MD: funding acquisition, investigation, methodology, project administration, resources, software, supervision, validation, original draft, review, editing Michael S. Ip, MD: methodology, project administration, supervision, original draft, review, editing Rahul N. Khurana, MD: investigation, review and editing Neal L. Oden, PhD: data curation, formal analysis, validation, original draft, review, editing

Andrew Hendrick, MD: No financial disclosures. Paul C. VanVeldhuisen, PhD: No financial disclosures. Ingrid U. Scott, MD, MPH: served on the Data and Safety Monitoring Committee and Safety Review Committee for clinical trials sponsored by Novartis. Jacquie King, MS: No financial disclosures. Barbara A. Blodi, MD: No financial disclosures. Michael S. Ip, MD: consultant for: Boehringer Ingelheim, Thrombogenics, Quark, Omeros, Allergan, Amgen, Astellas, Alimera; honorarium for research support for: Novartis, Genentech, Clearside, Biogen. Rahul N. Khurana, MD: consultant for Allergan, Genentech, and Regeneron; grant support from Allergan, Chengdu Kanghong, Clearside Biomedical, Roche, and Santen. Neal L. Oden, PhD: No financial disclosures.

Subjects:

Research Funding:

Supported by the National Eye Institute (National Institutes of Health, Department of Health and Human Services) grants U10EY023529, U10EY023533, and U10EY023521. Support also provided in part by Regeneron, Inc and Allergan, Inc through donation of investigational drug. This work was supported in part by an unrestricted grant from Research to Prevent Blindness, Inc. to the University of Wisconsin Madison Department of Ophthalmology and Visual Sciences and to the Jules Stein Eye Institute and Doheny Eye Institute, Department of Ophthalmology at the University of California Los Angeles, CA.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Ophthalmology
  • RETINAL VEIN OCCLUSION
  • INTRAVITREAL AFLIBERCEPT INJECTION
  • MACULAR EDEMA
  • SUSTAINED BENEFITS
  • 12-MONTH OUTCOMES
  • NATURAL-HISTORY
  • RANIBIZUMAB

SCORE2 Report 13: Intraretinal Hemorrhage Changes in Eyes With Central or Hemiretinal Bevacizumab or Observation. Secondary Analysis of the SCORE and SCORE2 Clinical Trials

Tools:

Journal Title:

AMERICAN JOURNAL OF OPHTHALMOLOGY

Volume:

Volume 222

Publisher:

, Pages 185-193

Type of Work:

Article | Post-print: After Peer Review

Abstract:

PURPOSE: To investigate the relationship between intraretinal macular hemorrhage and visual acuity outcomes in eyes with central retinal vein occlusion or hemiretinal vein occlusion managed with aflibercept, bevacizumab, or observation. DESIGN: Retrospective analysis of data from 2 randomized clinical trials. METHODS: A total of 362 participants were randomized in the Study of Comparative Treatments for Retinal Vein Occlusion 2, and 88 participants randomized to observation in the Standard Care vs Corticosteroid in Retinal Vein Occlusion Study. Participants received monthly intravitreal aflibercept or bevacizumab through month 6 or observation through month 8. The main outcome was visual acuity letter score (VALS). RESULTS: Reduced area of hemorrhage by month 6 was observed in 70.7% (116 of 164) of aflibercept-treated eyes, 63.8% (104 of 163) of bevacizumab-treated eyes, and 42.2% (27 of 64) of observation eyes by month 8 (P < .01). Relative to eyes with hemorrhage during follow-up, aflibercept-treated eyes without hemorrhage at month 6 had a mean VALS improvement of 8.0 (99% confidence interval [CI]: 1.9, 14.2); bevacizumab-treated eyes without hemorrhage at month 6 had a mean VALS improvement of 3.2 (99% CI: -4.6, 11.0); and observation eyes without hemorrhage at month 8 had a mean VALS improvement of 13.5 (99% CI: 0.4, 26.5). At month 6, the presence of hemorrhage and the change in central subfield thickness (CST) were significantly associated with the change in VALS; however, CST was a more important predictor. CONCLUSION: Improvement in hemorrhage during follow-up was associated with visual acuity improvements and predicted visual acuity changes beyond what was explained by CST. These findings suggest that intraretinal macular hemorrhage is an important indicator of disease severity in retinal vein occlusion.

Copyright information:

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/rdf).
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