Dietary Intake of Advanced Glycation End Products (AGEs) and Mortality among Individuals with Colorectal Cancer

• Authors: Ziling Mao, Emory University; Elom K Aglago, World Health Organization (IARC-WHO); Zhiwei Zhao, Emory University; Casper Schalkwijk, Maastricht University; Li Jiao, Baylor College of Medicine; Heinz Freisling, World Health Organization (IARC-WHO); Elisabete Weiderpass, World Health Organization (IARC-WHO); David J Hughes, University College Dublin; Anne K Eriksen, Danish Cancer Society Research Center; Anne Tjønneland, Danish Cancer Society Research Center; Gianluca Severi, Université Paris-Saclay; Joseph Rothwell, Université Paris-Saclay; Marie-Christine Boutron-Ruault, Université Paris-Saclay; Verena Katzke, German Cancer Research Center; Rudolf Kaaks, German Cancer Research Center; Matthias B Schulze, German Institute of Human Nutrition Potsdam-Rehbruecke; Anna Birukov, German Institute of Human Nutrition Potsdam-Rehbruecke; Vittorio Krogh, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano; Salvatore Panico, University of Naples Federico II; Rosario Tumino, Provincial Health Authority (ASP 7); Fulvio Ricceri, University of Turin; Bas H Bueno-de-Mesquita, National Institute for Public Health and the Environment (RIVM); Roel CH Vermeulen, Utrecht University; Inger T Gram, The Arctic University of Norway; Guri Skeie, The Arctic University of Norway; Torkjel M Sandanger, The Arctic University of Norway; Ramón J Quiros, Public Health Directorate, Spain; Marta Crous-Bou, Bellvitge Biomedical Research Institute (IDIBELL); Maria-Jose Sánchez, Escuela Andaluza de Salud Pública (EASP); Pilar Amiano, Ministry of Health of the Basque Government; María-Dolores Chirlaque, Instituto de Salud Carlos III; Aurelio Barricarte Gurrea, Instituto de Salud Carlos III; Jonas Manjer, Lund University; Ingegerd Johansson, Umea University; Aurora Perez-Cornago, University of Oxford; Mazda Jenab, World Health Organization (IARC-WHO); Veronika Fedirko, Emory University
• Journal Title: NUTRIENTS
• Volume: Volume 13, Number 12
• Publisher: MDPI | 2021-12-01
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.3390/nu13124435
• Subjects: Health Sciences, Epidemiology
• Keywords: Science & Technology; Life Sciences & Biomedicine; Nutrition & Dietetics; advanced glycation end-products; dietary advanced glycation end-products; all-cause mortality; colorectal cancer mortality; CORONARY-HEART-DISEASE; CARBOXYMETHYL-LYSINE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; BREAST-CANCER; ENDPRODUCTS; INFLAMMATION; GLYCOTOXINS; RISK; RESTRICTION

Abstract

Advanced glycation end-products (AGEs) may promote oxidative stress and inflammation and have been linked to multiple chronic diseases, including cancer. However, the association of AGEs with mortality after colorectal cancer (CRC) diagnosis has not been previously investigated. Multivariable Cox proportional hazards models were used to calculate hazard ratios and corresponding 95% confidence intervals for associations between dietary intake of AGEs with CRC-specific and all-cause mortality among 5801 participant cases diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition study between 1993 and 2013. Dietary intakes of AGEs were estimated using country-specific dietary questionnaires, linked to an AGE database, that accounted for food preparation and processing. During a median of 58 months of follow-up, 2421 cases died (1841 from CRC). Individually or combined, dietary intakes of AGEs were not associated with all-cause and CRC-specific mortality among cases. However, there was a suggestion for a positive association between AGEs and all-cause or CRC-specific mortality among CRC cases without type II diabetes (all-cause, Pinteraction = 0.05) and CRC cases with the longest follow-up between recruitment and cancer diagnosis (CRC-specific, Pinteraction = 0.003; all-cause, Pinteraction = 0.01). Our study suggests that pre-diagnostic dietary intakes of AGEs were not associated with CRC-specific or all-cause mortality among CRC patients. Further investigations using biomarkers of AGEs and stratifying by sex, diabetes status, and timing of exposure to AGEs are warranted.