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  • Antiseptics
  • Benzalkonium chloride
  • Methicillin-resistant Staphylococcus aureus (MRSA)
  • Quaternary ammonium compounds
  • Trivalent sulfonium compounds
  • Bacteria
  • Dose-Response Relationship, Drug
  • Erythrocytes
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Quaternary Ammonium Compounds
  • Structure-Activity Relationship
  • Sulfonium Compounds
  • Surface-Active Agents
  • Thiophenes

Trivalent sulfonium compounds (TSCs): Tetrahydrothiophene-based amphiphiles exhibit similar antimicrobial activity to analogous ammonium-based amphiphiles


Journal Title:

Bioorganic and Medicinal Chemistry Letters


Volume 37, Number


, Pages 127809-127809

Type of Work:



Recent advances in the development of quaternary ammonium compounds (QACs) have focused on new structural motifs to increase bioactivity, but significantly less studied has been the change from ammonium- to sulfonium-based disinfectants. Herein, we report the synthesis of structurally analogous series of quaternary ammonium and trivalent sulfonium compounds (TSCs). The bioactivity profiles of these compounds generally mirror each other, and the antibacterial activity of sulfonium-based THT-18 was found to be comparable to the commercial disinfectant, BAC. The development of these compounds presents a new avenue for further study of disinfectants to combat the growing threat of bacterial resistance.
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