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Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Biochemistry & Molecular Biology
  • Biology
  • Cell Biology
  • Life Sciences & Biomedicine - Other Topics
  • assisted reproductive technologies
  • developmental origins of health and disease
  • long&#8208
  • term health
  • metabolic outcomes
  • sex&#8208
  • specific
  • ASSISTED REPRODUCTIVE TECHNOLOGIES
  • ELEMENT-BINDING PROTEIN-1C
  • DEVELOPMENTAL ORIGINS
  • VASCULAR DYSFUNCTION
  • INSULIN-RESISTANCE
  • MASS-SPECTROMETRY
  • HEALTH OUTCOMES
  • GENE-EXPRESSION
  • MESSENGER-RNA
  • LIVER

Sex-specific effects of in vitro fertilization on adult metabolic outcomes and hepatic transcriptome and proteome in mouse

Tools:

Journal Title:

FASEB JOURNAL

Volume:

Volume 35, Number 4

Publisher:

, Pages e21523-e21523

Type of Work:

Article

Abstract:

Although in vitro fertilization (IVF) is associated with adverse perinatal outcomes, there is increasing concern about the long-term and sex-specific health implications. Augmenting our IVF mouse model to longitudinally investigate metabolic outcomes in offspring from optimal neonatal litter sizes, we found sex-specific metabolic outcomes in IVF offspring. IVF-conceived females had higher body weight and cholesterol levels compared to naturally conceived females, whereas IVF-conceived males had higher levels of triglycerides and insulin, and increased body fat composition. Through adult liver transcriptomics and proteomics, we identified sexually dimorphic dysregulation of the sterol regulatory element-binding protein (SREBP) pathways that are associated with the sex-specific phenotypes. We also found that global loss of DNA methylation in placenta was linked to higher cholesterol levels in IVF-conceived females. Our findings indicate that IVF procedures have long-lasting sex-specific effects on metabolic health of offspring and lay the foundation to utilize the placenta as a predictor of long-term outcomes.
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