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Hongqian Guo, Email:dr.ghq@nju.edu.cn
J.Y. and Z.L. conceived of and designed the project. Q.W. and J.Y. wrote the manuscript with input from all other authors. Y.F., X.Z., K.Z., S.J., and H.G. prepared the paracancerous and tumor samples. Y.Z. generated scATAC-seq libraries and performed the immunofluorescence staining experiments; Q.W. designed the data analysis plan and optimized Cicero. Q.W. and B.Z. performed data analysis with assistance from Z.Q., E.L., Y.X., and J.Z.. All authors read and approved the final manuscript.
We thank Dr. Si Wei for insightful discussion and thank Ai Lin Chun for critically reading and editing the manuscript.
The authors have declared that no conflict of interest exists.
We are grateful to support from the National Natural Science Foundation of China (81500515, J.Y.), Natural Science Foundation of Jiangsu Province (BK20150591, J.Y.), Nanjing University and Emory University Collaborative Research Grants (NE2019003, J.Y.), the Fundamental Research Funds for the Central University (021114380172, J.Y.), Jiangsu Clinical Medical Center (innovation platform, YXZXA2016003, Z.L.), The Open Project of Jiangsu Biobank of Clinical Resources (JSRB2021-01, J.Y.).
© The Author(s) 2022