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Yuhui Du, Email: duyuhui@sxu.edu.cn
Y.D. proposed the whole analysis framework and implemented the analyses on spatial networks from ICA, functional connectivity network, ROI-based connectivity, gray matter volume and density, as well as the association analyses between neuroimaging measures and medication/symptom scores. Y.D. drafted and revised the whole manuscript, and prepared the tables and figures. Y.D. programed the orginial code of GIG-ICA. Z.F. downloaded and organized the datasets, preprocessed the fMRI and sMRI data, performed brain mask generation and GIG-ICA on each dataset, drafted, and revised the paper. Y.X. performed the classification experiments under the guidance of Y.D. D.L. preprocessed the COBRE and FBIRN datasets, and edited the paper. A.A., M.S., and S.Q. discussed the framework and revised the paper. P.K. and L.E.H. provided the MPRC data and revised the paper. G.P. edited the paper. V.D.C. supervised the work and edited the paper. All authors have given final approval of this version of the article.
Special thanks to Srinivas Rachakonda, as he added the GIG-ICA method to the GIFT toolbox and provided the batch script for performing GIG-ICA more easily. We also acknowledge the FBIRN team who coordinated and performed the data acquisition including Theo G.M. van Erp, Aysenil Belger, Juan R. Bustillo, Kelvin O. Lim, Daniel S. O’Leary, Judith M. Ford, Daniel H. Mathalon, Jessica A. Turner, and Steven G. Potkin.
The authors declare no competing interests.
This work was supported by National Natural Science Foundation of China (Grant number 62076157 and 61703253, to Y.D.), Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province (to Y.D.), the 1331 Engineering Project of Shanxi Province of China, and the National Institutes of Health grant (Grant number R01MH118695, to V.D.C.).
© The Author(s) 2021