About this item:

7 Views | 4 Downloads

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Pharmacology & Pharmacy
  • NATURAL-PRODUCTS
  • DISCOVERY

Phylogeny-Guided Approach Yields Glycopeptides with Unique Action

Tools:

Journal Title:

TRENDS IN PHARMACOLOGICAL SCIENCES

Volume:

Volume 41, Number 5

Publisher:

, Pages 297-299

Type of Work:

Article

Abstract:

Bacteria are extremely adept at overcoming the effects of antibiotics through a variety of mechanisms. As a result, researchers are constantly searching for antibiotics with new mechanisms of action. Culp and coworkers recently utilized a phylogeny-guided approach to mine the genomes of Actinomycetes species for glycopeptides with novel targets. Their efforts yielded the identification of complestatin and corbomycin as antibiotics with a different target than other glycopeptides.
Export to EndNote