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Author Notes:

Correspondence: cdnwagw@emory.edu

Author contributions: Conceptualization, C.D.N. and A.-M.C.; methodology, C.D.N., A.V.I., M.Y.J., D.C.A.; validation, A.-M.C. and D.C.A.; investigation, C.D.N., A.V.I., M.Y.J. and O.A.; data curation, C.D.N. and A.V.I.; writing—original draft preparation, C.D.N., A.V.I., M.Y.J. and O.A.; writing—review and editing, D.C.A.; visualization, C.D.N. All authors have read and agreed to the published version of the manuscript.

Disclosures: Anne-Marie Carbonell is the President and CEO of OncoSynergy, Inc. (manufacturer of OS2966) and holds an equity interest in the company. The rest of the authors declare no conflict of interest.

Subjects:

Research Funding:

This research received no external funding.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Pharmacology & Pharmacy
  • glioblastoma
  • high-grade glioma
  • refractory glioma
  • direct delivery
  • convection enhanced delivery
  • neuro-oncology
  • refractory glioblastoma
  • clinical trials
  • Targeted toxin
  • Intracerebral haemorrhage
  • Gene-therapy
  • Glioblastoma
  • Infusion
  • Trial
  • Paclitaxel
  • Phase-I
  • Safety

Convection Enhanced Delivery in the Setting of High-Grade Gliomas

Tools:

Journal Title:

Pharmaceutics

Volume:

Volume 13, Number 4

Publisher:

Type of Work:

Article | Final Publisher PDF

Abstract:

Development of effective treatments for high-grade glioma (HGG) is hampered by (1) the blood–brain barrier (BBB), (2) an infiltrative growth pattern, (3) rapid development of therapeutic resistance, and, in many cases, (4) dose-limiting toxicity due to systemic exposure. Convection-enhanced delivery (CED) has the potential to significantly limit systemic toxicity and increase therapeutic index by directly delivering homogenous drug concentrations to the site of disease. In this review, we present clinical experiences and preclinical developments of CED in the setting of high-grade gliomas.

Copyright information:

© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/rdf).
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