About this item:

14 Views | 5 Downloads

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Chemistry, Medicinal
  • Pharmacology & Pharmacy
  • antiseptics
  • benzalkonium chloride
  • bisQAC
  • ferrocene
  • methicillin-resistant Staphylococcus aureus (MRSA)
  • quaternary ammonium compounds
  • QUATERNARY AMMONIUM-COMPOUNDS
  • ANTIBACTERIAL
  • AMPHIPHILES
  • ANTISEPTICS
  • FLUIDITY

Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures

Tools:

Journal Title:

CHEMMEDCHEM

Volume:

Volume 16, Number 3

Publisher:

, Pages 467-471

Type of Work:

Article

Abstract:

Inspired by the incorporation of metallocene functionalities into a variety of bioactive structures, particularly antimicrobial peptides, we endeavored to broaden the structural variety of quaternary ammonium compounds (QACs) by the incorporation of the ferrocene moiety. Accordingly, 23 ferrocene-containing mono- and bisQACs were prepared in high yields and tested for activity against a variety of bacteria, including Gram-negative strains and a panel of clinically isolated MRSA strains. Ferrocene QACs were shown to be effective antiseptics with some displaying single-digit micromolar activity against all bacteria tested, demonstrating yet another step in the expansion of structural variety of antiseptic QACs.
Export to EndNote