Spontaneous cortical MEG activity undergoes unique age- and sex-related changes during the transition to adolescence

• Authors: Lauren R Ott, Boys Town National Research Hospital; Samantha H Penhale, Boys Town National Research Hospital; Brittany K Taylor, Boys Town National Research Hospital; Brandon J Lew, Boys Town National Research Hospital; Yu-Ping Wang, Tulane University; Vince D Calhoun, Georgia State University; Julia M Stephen, The Mind Research Network; Tony W Wilson, Boys Town National Research Hospital
• Journal Title: NeuroImage
• Volume: Volume 244
• Publisher: Elsevier | 2021-12-01, Pages 118552-118552
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1016/j.neuroimage.2021.118552
• Subjects: Engineering, Biomedical; Health Sciences, Pharmacology
• Keywords: Development; Frequency; Magnetoencephalography (MEG); Power; Resting state; Adolescent; Age Factors; Brain Waves; Child; Female; Frontal Lobe; Humans; Magnetic Resonance Imaging; Magnetoencephalography; Male; Puberty; Sex Characteristics; Temporal Lobe

Abstract

Background: While numerous studies have examined the developmental trajectory of task-based neural oscillations during childhood and adolescence, far less is known about the evolution of spontaneous cortical activity during this time period. Likewise, many studies have shown robust sex differences in task-based oscillations during this developmental period, but whether such sex differences extend to spontaneous activity is not understood. Methods: Herein, we examined spontaneous cortical activity in 111 typically-developing youth (ages 9–15 years; 55 male). Participants completed a resting state magnetoencephalographic (MEG) recording and a structural MRI. MEG data were source imaged and the power within five canonical frequency bands (delta, theta, alpha, beta, gamma) was computed. The resulting power spectral density maps were analyzed via vertex-wise ANCOVAs to identify spatially-specific effects of age, sex, and their interaction. Results: We found robust increases in power with age in all frequencies except delta, which decreased over time, with findings largely confined to frontal cortices. Sex effects were distributed across frontal and temporal regions; females tended to have greater delta and beta power, whereas males had greater alpha. Importantly, there was a significant age-by-sex interaction in theta power, such that males exhibited decreasing power with age while females showed increasing power with age in the bilateral superior temporal cortices. Discussion: These data suggest that the strength of spontaneous activity undergoes robust change during the transition from childhood to adolescence (i.e., puberty onset), with intriguing sex differences in some cortical areas. Future developmental studies should probe task-related oscillations and spontaneous activity in parallel.