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Liming Cheng, Email: limingcheng@tongji.edu.cn OR Keqiang Ye, Email: kye@emory.edu
K.Y. designed research; Z.W., C.C., S.S.K., X.L., X.G., and S.P.Y. performed research; C.D.K. contributed new reagents/analytic tools; Z.W., X.G., S.P.Y., L.C., and K.Y. analyzed data; and C.D.K. and K.Y. wrote the paper.
We thank the University of Washington ADRC (NIH Grant No. P50AG005136) and the Kaiser Permanente Adult Changes in Thought Study (NIH Grant No. U01 AG006781) research subjects and their families for brain donation, a tremendous gift to science. We thank Ms. Allison Beller for coordination of tissue requests, subject selection, and tissue transfer and Ms. Kim Howard for histological support.
The authors declare no competing interest.
University of Washington ADRC (NIH Grant No. P50AG005136), (NIH Grant No. U01 AG006781)
This study was supported in part by the Rodent Behavioral Core, which is subsidized by the Emory University School of Medicine and is one of the Emory Integrated Core Facilities. Additional support was provided by the Viral Vector Core of the Emory Neuroscience National Institute of Neurological Disorders and Stroke (NINDS) Core Facilities (Grant No. P30NS055077).
Further support was provided by the Georgia Clinical & Translational Science Alliance of the NIH under Award No. UL1TR002378. This work is supported by a grant from the NIH (RF1, Grant No. AG051538; RO1, Grant No. NS105982), and the ADRC center grant (P30, Grant No. AG066511) to K.Y., the Funds for International Cooperation and Exchange of the National Natural Science Foundation of China (NSFC) (Grant No. 81810001048), the National Basic Research Program of China (Grant No. 2016YFA0100800) to L.C., Shanghai Pujiang Program (Grant No. 19PJ1409200), and the National Natural Science Foundation of China (Grant No. 82071370) to Z.W. C.D.K. was supported by the Nancy and Buster Alvord Endowment