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Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Immunology
  • Neurosciences
  • Neurosciences & Neurology
  • HIV
  • AIDS
  • Cognition
  • Cerebrospinal fluid
  • Flow cytometry
  • CD8(+) T-CELLS
  • HUMAN-IMMUNODEFICIENCY-VIRUS
  • CENTRAL-NERVOUS-SYSTEM
  • ACTIVATION
  • BLOOD
  • IMPAIRMENT
  • PHENOTYPES
  • PROTEIN
  • CSF

Distinct cellular immune properties in cerebrospinal fluid are associated with cognition in HIV-infected individuals initiating antiretroviral therapy

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Journal Title:

JOURNAL OF NEUROIMMUNOLOGY

Volume:

Volume 344, Number

Publisher:

, Pages 577246-577246

Type of Work:

Article

Abstract:

We examined the relationship between CSF immune cells and neurocognition and neuronal damage in HIV+ individuals before and after initiating antiretroviral therapy. Multivariate analysis at baseline indicated that greater CD4+ T cell abundance was associated with better cognition (p =.017), while higher CSF HIV RNA was associated with increased neuronal damage (p =.014). Following 24 weeks of antiretroviral therapy, CD8+ T cells, HLA-DR expressing CD4+ and CD8+ T cells, B cells, NK cells, and non-classical monocyte percentage decreased in CSF. Female gender was negatively associated with cognitive performance over time, as was higher percentage of HLA-DR expressing CD8+ T cells at baseline.
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