Kinetics of maternally-derived serogroup A, C, Y and W-specific meningococcal immunoglobulin G in Malian women and infants

• Authors: H Findlow, Vaccine Evaluation Unit; MD Tapia, University of Maryland School of Medicine; SO Sow, Centre pour le Développement des Vaccins; FC Haidar, Centre pour le Développement des Vaccins; F Coulibaly, Centre pour le Développement des Vaccins; AM Keita, Centre pour le Développement des Vaccins; F Diallo, Centre pour le Développement des Vaccins; M Doumbia, Centre pour le Développement des Vaccins; A Traore, Centre pour le Développement des Vaccins; N Schluterman, Centre pour le Développement des Vaccins; DA Clark, Emory University; R Borrow, Public Health England; MM Levine, University of Maryland School of Medicine
• Journal Title: VACCINE
• Volume: Volume 37, Number 18
• Publisher: Elsevier | 2019-04-24, Pages 2477-2481
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.1016/j.vaccine.2019.03.045
• Subjects: Health Sciences, Epidemiology
• Keywords: Meningococcal; Maternal immunization; Vaccination

Abstract

A prospective, randomised, controlled observer-blind trial measuring the efficacy and immunogenicity of trivalent influenza vaccine (TIV) and the immunogenicity of quadrivalent meningococcal conjugate vaccine (MCV) in pregnant women and their infants up to 6 months of age was conducted in Mali. Here we reported the immunogenicity of MCV, which was used as a comparator vaccine to TIV, in this population. Third-trimester pregnant Malian women were randomized to receive TIV or MCV. Blood samples were collected from women prior to vaccination, 28 days post-vaccination, at delivery and 3 and 6 months post-delivery and from infants at birth and 3 and 6 months of age. Meningococcal-specific serogroup (Men) A, C, Y and W-specific antibodies were measured by enzyme linked immunosorbent assay in a randomly selected subset of 50 mother-infant pairs where the mother had received MCV. At birth, 94.0% (47/50) of infants had MenA specific IgG levels ≥ 2 µg/mL decreasing to 72.9% and 30.4% at 3 and 6 months of age. For MenC, 81.3% (39/48) of infants had MenC specific IgG levels ≥ 2 µg/mL at birth decreasing to 29.4% and 17.8% at 3 and 6 months of age. For MenY, 89.6% (43/48) of infants had MenY specific IgG levels ≥ 2 µg/mL at birth decreasing to 64.6% and 62.5% at 3 and 6 months of age. For MenW, 89.6% (43/48) of infants had MenW specific IgG levels ≥ 2 μg/ml at birth decreasing to 62.5% and 41.7% at 3 and 6 months of age.