Intrinsic neural network dynamics in catatonia

• Authors: Fabio Sambataro, University of Padova; Dusan Hirjak, Heidelberg University; Stefan Fritze, Heidelberg University; Katharina M Kubera, Heidelberg University; Georg Northoff, University of Ottawa; Vince D Calhoun, Emory University; Andreas Meyer-Lindenberg, Heidelberg University; Robert C Wolf, Heidelberg University
• Journal Title: HUMAN BRAIN MAPPING
• Volume: Volume 42, Number 18
• Publisher: Wiley Periodicals LLC | 2021-09-29, Pages 6087-6098
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.1002/hbm.25671
• Subjects: Health Sciences, Mental Health; Health Sciences, Medicine and Surgery
• Keywords: catatonia; dynamic functional network connectivity; MRI; sensorimotor neuroscience; static functional network connectivity

Abstract

Catatonia is a transnosologic psychomotor syndrome with high prevalence in schizophrenia spectrum disorders (SSD). There is mounting neuroimaging evidence that catatonia is associated with aberrant frontoparietal, thalamic and cerebellar regions. Large‐scale brain network dynamics in catatonia have not been investigated so far. In this study, resting‐state fMRI data from 58 right‐handed SSD patients were considered. Catatonic symptoms were examined on the Northoff Catatonia Rating Scale (NCRS). Group spatial independent component analysis was carried out with a multiple analysis of covariance (MANCOVA) approach to estimate and test the underlying intrinsic components (ICs) in SSD patients with (NCRS total score ≥ 3; n = 30) and without (NCRS total score = 0; n = 28) catatonia. Functional network connectivity (FNC) during rest was calculated between pairs of ICs and transient changes in connectivity were estimated using sliding windowing and clustering (to capture both static and dynamic FNC). Catatonic patients showed increased static FNC in cerebellar networks along with decreased low frequency oscillations in basal ganglia (BG) networks. Catatonic patients had reduced state changes and dwelled more in a state characterized by high within‐network correlation of the sensorimotor, visual, and default‐mode network with respect to noncatatonic patients. Finally, in catatonic patients according to DSM‐IV‐TR (n = 44), there was a significant correlation between increased within FNC in cortico‐striatal state and NCRS motor scores. The data support a neuromechanistic model of catatonia that emphasizes a key role of disrupted sensorimotor network control during distinct functional states.