About this item:

20 Views | 15 Downloads

Author Notes:

S. A. Factor, Email: sfactor@emory.edu

J.M.H.-M.: Co-first author, research project-conception, organization, execution, statistical analysis—review and critique, manuscript—review and critique, arranged funding. J.L.M.: Co-first author, research project-execution, statistical analysis—execution, manuscript—writing of the first draft, review, and critique. A.F.P.: research project-no role, statistical analysis—execution, manuscript—review and critique. B.S.: Research project-execution, statistical analysis-no role, manuscript— review and critique. J.C.H.: Research project-execution, statistical analysis-no role, manuscript—review and critique. F.C.G.: Research project-execution, statistical analysis—review and critique, manuscript—review and critique. L.W.: Research project-no role, statistical analysis—review and critique, manuscript—review and critique. W.T.H.: Research project-execution, statistical analysis—review and critique, manuscript—review and critique. S.A.F.: Research project: conception, organization, execution, statistical analysis—review and critique; manuscript—Writing of the first draft, arranged funding.

Dr. Hatcher-Martin has the following disclosures: Honoraria: Acadia, Neurocrine, Parkinson’s Foundation. Dr. McKay has the following disclosures: Consulting fees: Biocircuit Technologies. Ms. Pybus has nothing to disclose. Ms. Howell has nothing to disclose. Dr. Goldstein reports no disclosures. Dr. Wood has nothing to disclose. Dr. Hu has patent or patent-pending on CSF diagnosis of FTLD-TDP, CSF prognosis of SMA, and serological assays for COVID-19; licensed serological assays for COVID-19 to Sigma-Millipore; consulted for Biogen Inc., Fujirebio Diagnostics Inc., Apellis Pharmaceuticals, and AARP; and received research support from Fujirebio Diagnostics Inc. Dr. Factor has the following disclosures: Honoraria: Lundbeck, Teva, Sunovion, Biogen, Acadia, Neuroderm, Acorda, CereSpire. Grants: Ipsen, Medtronic, Boston Scientific, Teva, US World Meds, Sunovion Therapeutics, Vaccinex, Voyager, Jazz Pharmaceuticals, Lilly, CHDI Foundation, Michael J. Fox Foundation, Royalties: Demos, Blackwell Futura for textbooks, Uptodate Other Bracket Global LLC, CNS Ratings LLC.

Subjects:

Research Funding:

William N. and Bernice E. Bumpus Foundation (J.M.H.-M.), Curtis family Fund; Sartain Lanier Family Foundation (S.A.F.); American Parkinson’s Disease Association; NIH K25 HD086276 (J.L.M.); NIH R01 54046 (W.T.H.).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Neurosciences
  • Neurosciences & Neurology
  • ALZHEIMERS-DISEASE
  • BETA LEVELS
  • CSF
  • A-BETA(42)
  • ASSOCIATION
  • P-TAU(181)
  • SUBTYPES
  • SLEEP
  • FALLS
  • LIFE

Cerebrospinal fluid biomarkers in Parkinson's disease with freezing of gait: an exploratory analysis

Tools:

Journal Title:

NPJ PARKINSONS DISEASE

Volume:

Volume 7, Number 1

Publisher:

, Pages 105-105

Type of Work:

Article | Final Publisher PDF

Abstract:

We explore the association between three Alzheimer’s disease-related and ten inflammation-related CSF markers and freezing of gait (FOG) in patients with Parkinson’s disease (PD). The study population includes PD patients with FOG (PD-FOG, N = 12), without FOG (PD-NoFOG, N = 19), and healthy controls (HC, N = 12). Age and PD duration are not significantly different between groups. After adjusting for covariates and multiple comparisons, the anti-inflammatory marker, fractalkine, is significantly decreased in the PD groups compared to HC (P = 0.002), and further decreased in PD-FOG compared to PD-NoFOG (P = 0.007). The Alzheimer’s disease-related protein, Aβ42, is increased in PD-FOG compared to PD-NoFOG and HC (P = 0.001). Group differences obtained in individual biomarker analyses are confirmed with multivariate discriminant partial least squares regression (P < 0.001). High levels of Aβ42 in PD-FOG patients supports an increase over time from early to advanced state. Low levels of fractalkine might suggest anti-inflammatory effect. These findings warrant replication.

Copyright information:

© The Author(s) 2021

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/rdf).
Export to EndNote