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Ramya Ganesan, Department of Medicine, Emory University, School of Medicine, Health Sciences Research Building E269(E2,F2),1760 Haygood Dr, Atlanta, GA 30322, USA. Email: ramya.ganesan@emory.edu
R.G. designed the study, performed experiments and data analysis, prepared figures and wrote the manuscript. J.G.C. conceived and supervised research, contributed to manuscript preparation and critically edited the manuscript. K.M.H. and K.S. carried out experiments and data analysis and contributed to manuscript and figure preparation. C.N.S supervised research and contributed to manuscript preparation and critically edited the manuscript. N.R.C contributed to data analysis and critically edited the manuscript. X.d.l.R. and S.L. performed and analyzed experiments, contributed to manuscript preparation and revision.
We thank Dr. Yasunori Kanaho and Dr. Gilbert Di Paolo for providing us the PLD2 and PLD1 knockout mice, respectively. We thank Dr. Kristen Fite for helpful suggestions and comments on this study. This work is dedicated in loving memory of our dearest colleague, mentor and friend, Prof. Julian Gomez-Cambronero. The experiments reported herein were initiated while Dr. Gomez-Cambronero was on sabbatical in the CNS lab in Boston before his untimely passing.
The authors declare no competing financial interests.
The following grants to Dr. Cambronero (J.G.C) have supported this work: HL056653-14 from the National Institutes of Health (NIH) and 13GRNT17230097 from the American Heart Association. Experiments in the CNS lab Boston,MA were supported by National Institutes of Health grant P01GM095467 (CNS).