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Edward A. Botchwey, The Parker H. Petit Institute for Bioengineering & Bioscience, 315 Ferst Dr NW, Atlanta, GA 30332; E-mail: edward.botchwey@bme.gatech.edu
J.S. and H.S. designed and performed experiments, collected and analyzed data, and wrote the manuscript; C.R. performed the microCT analysis; S.D. performed the osteoclast western blots, cathepsin zymography, and data analysis; A.A. and K.B. analyzed data; N.T. edited the manuscript; and E.A.B. and M.O.P. served as principal advisors and contributed to experimental design and manuscript editing.
The authors thank Georgia Tech Petit Institute for Bioengineering and Bioscience core facility managers, Steven Woodard, Angela Lin, and Sommer Durham, and all the animal facility staff.
The authors declare no competing financial interests.
The work was supported by grants from the National Institutes of Health (NIH) (National Institute of Arthritis and Musculoskeletal and Skin Diseases, R01AR056445; National Institute of Dental and Craniofacial Research, R01DE019935), grants from the Department of Defense (W81XWH-10-1-0928, E.A.B.) and the NIH (National Heart, Lung, and Blood Institute, R56HL136210-01, M.O.P.), and by the American Heart Association Grant-in-Aid (17GRNT33710016, M.O.P.).
The study was in part supported by the Regenerative Engineering and Medicine Center’s “Georgia Partners in Regenerative Medicine” seed grants and the Marcus Center for Therapeutic Cell Characterization and Manufacturing (MC3 M) research grant (E.A.B.). It was also supported by the National Science Foundation grant NSF GRFP DGE-1148903, an NIH/National Institute of General Medical Sciences Cells and Tissue Engineering Biotechnology training grant (T32GM008433), and the Alfred P. Sloan graduate fellowship awarded to J.S
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