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Author Notes:

Vineet Tiruvadi, Email: vitruva@emory.edu

VT, KC, RG, and HM experimental design. VT, RG, and HM data acquisition. VT, RB, VJ, and HM analyzes. VT manuscript preparations. All authors provided feedback on drafts and approved the final manuscript.

We thank S. Quinn and L. Denison for their work in trial administration and coordination. We acknowledge the help of A. Veerakumar and A. Waters in data collection. A special thank you to the patients who participated in this study and were incredible collaborators.

HM report consulting and intellectual licensing fees from Abbott Labs. RG serves as a consultant to and receives research support from Medtronic, and serves as a consultant to Abbott Labs. The terms of these arrangements have been reviewed and approved by Emory University in accordance with its conflict of interest policies. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Subjects:

Research Funding:

Funding support was provided by the Whitaker International Foundation, National Institutes of Health (UH3NS103550), Hope for Depression Research Foundation and European Union's Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 945539 (Human Brain Project SGA3). Implanted devices used in the work were donated by Medtronic, Inc. (Minneapolis, MN).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Neurosciences
  • Neurosciences & Neurology
  • subcallosal
  • cingulate
  • DBS
  • dynamics
  • tractography
  • SUBTHALAMIC NUCLEUS
  • ACTIVATION
  • MECHANISMS

Dynamic Oscillations Evoked by Subcallosal Cingulate Deep Brain Stimulation

Journal Title:

FRONTIERS IN NEUROSCIENCE

Volume:

Volume 16

Publisher:

, Pages 768355-768355

Type of Work:

Article | Final Publisher PDF

Abstract:

Deep brain stimulation (DBS) of subcallosal cingulate white matter (SCCwm) alleviates symptoms of depression, but its mechanistic effects on brain dynamics remain unclear. In this study we used novel intracranial recordings (LFP) in n = 6 depressed patients stimulated with DBS around the SCCwm target, observing a novel dynamic oscillation (DOs). We confirm that DOs in the LFP are of neural origin and consistently evoked within certain patients. We then characterize the frequency and dynamics of DOs, observing significant variability in DO behavior across patients. Under the hypothesis that LFP-DOs reflect network engagement, we characterize the white matter tracts associated with LFP-DO observations and report a preliminary observation of DO-like activity measured in a single patient's electroencephalography (dEEG). These results support further study of DOs as an objective signal for mechanistic study and connectomics guided DBS.

Copyright information:

© 2022 Tiruvadi, Choi, Gross, Butera, Jirsa and Mayberg

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/rdf).
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