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Rui-Ping Xiao, Email: xiaor@pku.edu.cn Yan Zhang, Email: zhangyan9876@pku.edu.cn
H.F., H.S., Y.Z., and R.-P.X. proposed the hypothesis, generated the initial idea, conducted key experiments, and wrote the manuscript. Y.Z. and R.-P.X. designed the study, supervised the experiments and data analysis, wrote the manuscript, and interpreted the results. M.J.R., Y.-H.W., H.-K.W., F.L., and X.H. researched data and contributed to discussion. G.-J.C., S.Z., P.X., L.J., Y.H., and Y.W. researched data. Y.Z. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
The authors thank Drs. H.P. Cheng for insightful discussions and H. Shang, W. Zheng, W.Q. Zhang, and X.T. Sun for excellent technical support. The authors also thank Drs. H. Takeshima and J.J. Ma for providing the Mg53−/− mice.
No potential conflicts of interest relevant to this article were reported.
This work was supported by the National Key R&D Program of China (2018YFA0507603, 2018YFA0800701, and 2018YFA0800501) and the National Natural Science Foundation of China (31671177, 81630008, 81790621, 31970722, and 31521062).
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