Indole derivatives, microbiome and graft versus host disease

• Authors: Muna Qayed, Emory University; David Michonneau, Saint Louis Hospital, France; Gerard Socie, Saint Louis Hospital, France; Edmund Waller, Emory University
• Journal Title: CURRENT OPINION IN IMMUNOLOGY
• Volume: Volume 70
• Publisher: CURRENT BIOLOGY LTD | 2021-06-01, Pages 40-47
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1016/j.coi.2021.02.006
• Subjects: Health Sciences, Public Health
• Keywords: Science & Technology; Life Sciences & Biomedicine; Immunology; ARYL-HYDROCARBON RECEPTOR; INTESTINAL MICROBIOTA; STEM-CELL; T-CELLS; TRYPTOPHAN-METABOLISM; GUT MICROBIOME; IMMUNITY; AHR; 2,3-DIOXYGENASE; TRANSPLANTATION

Abstract

Graft versus host disease is a life-threatening complication following allogeneic hematopoietic stem cell transplantation driven by donor T cells reacting against disparate host antigens. Immune homeostasis within the gut plays a major role in the graft versus host response. Gut microbiota and its metabolites impact gut integrity, inflammation and immune activation within the gut. This review will focus on the role of indoles, a product of microbiota metabolism, on gut homeostasis and our current understanding on how that modulates graft versus host disease.