Cardiac vagal control in response to acute stress during pregnancy: Associations with life stress and emotional support

• Authors: Irene Tung, University of Pittsburgh; Robert Krafty, Emory University; Meaghan L Delcourt, University of Pittsburgh; Nadine M Melhem, University of Pittsburgh; Richard J Jennings, University of Pittsburgh; Kate Keenan, University of Chicago; Alison E Hipwell, University of Pittsburgh
• Journal Title: PSYCHOPHYSIOLOGY
• Volume: Volume 58, Number 6
• Publisher: WILEY | 2021-03-13, Pages e13808-e13808
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1111/psyp.13808
• Subjects: Biology, Neuroscience; Health Sciences, Mental Health; Biology, Biostatistics
• Keywords: Social Sciences; Science & Technology; Life Sciences & Biomedicine; Psychology, Biological; Neurosciences; Physiology; Psychology; Psychology, Experimental; Neurosciences & Neurology; cardiac vagal control; ECG; emotional support; heart rate; heart rate variability; HRV; life stress; pregnancy; prenatal stress; RMSSD; Trier Social Stress Test; HEART-RATE-VARIABILITY; LOW-INCOME; SOCIAL SUPPORT; RESILIENCE; WOMEN; REACTIVITY; EVENTS

Abstract

Life stressors during pregnancy can disrupt maternal stress regulation and negatively impact offspring health. Despite the important role of cardiac vagal control (e.g., heart rate variability; HRV) in stress regulation, few studies have investigated how life stressors and emotional support influence vagal control during pregnancy. This study aimed to (a) characterize patterns of cardiac vagal control in response to a stressor administered in pregnancy, and (b) examine the effects of life stress and emotional support on vagal control during rest, reactivity, and recovery. Participants included 191 pregnant women (79% Black; 21% White) living in an urban U.S. city (73% receiving public assistance). Heart rate (HR) and HRV (indexed by RMSSD) were recorded continually during the preparation, task, and recovery periods of the Trier Social Stress Test (TSST). Participants reported recent life stressors (e.g., relationship problems, financial hardship) and emotional support. Piecewise growth curve modeling was used to model rates of reactivity and recovery, adjusting for gestational age at time of assessment and recent health problems. Life stress predicted greater HR and HRV reactivity to the TSST as well as greater HRV recovery (vagal rebound). However, associations were only evident for women reporting high emotional support. Results suggest that pregnant women living with frequent life stressors may exhibit more rapid autonomic responses to acute stress, including more rapid vagal rebound after stressors, potentially reflecting physiological adaptation to anticipated high-stress environments; emotional support may enhance these responses. Studies are needed to investigate long-term health outcomes related to this stress response pattern.