Disruptions in global network segregation and integration in adolescents and young adults with Fetal Alcohol Spectrum Disorder

• Authors: Carlos I Rodriguez, The Mind Research Network. 1101 Yale Blvd; Victor Vergara, Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS); Vince Calhoun, Emory University; Daniel D Savage, University of New Mexico School of Medicine.; Derek A Hamilton, University of New Mexico School of Medicine.; Claudia D Tesche, University of New Mexico; Julia M Stephen, The Mind Research Network. 1101 Yale Blvd
• Journal Title: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
• Volume: Volume 45, Number 9
• Publisher: Wiley | 2021-08-02, Pages 1775-1789
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1111/acer.14673
• Subjects: Biology, Neuroscience; Psychology, Clinical
• Keywords: Prenatal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Graph Theory; Functional Network Connectivity; functional MRI (fMRI)

Abstract

Fetal Alcohol Spectrum Disorder (FASD) represents a significant public health concern that is associated with a broad range of physical, neurocognitive, and behavioral effects associated with prenatal alcohol exposure (PAE). Magnetic resonance imaging (MRI) has been an important tool for advancing our knowledge of abnormal brain structure and function in individuals with FASD. However, only a small number of studies have applied graph theory-based network analysis to resting state functional MRI (fMRI) data in individuals with FASD highlighting a need for additional research in this area.