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Brian D. Evavold, Email: brian.evavold@path.utah.edu
B.L., J.D.H., and B.D.E. designed the experiments. B.L., J.D.H., and E.M.K. obtained 2D affinity data. B.L., J.D.H., and D.M.W. obtained T-cell functional data. B.L., J.D.H., and B.D.E. designed the experiments. B.L., J.D.H., and B.D.E. wrote the manuscript. D.A.V. and M.B. contributed to writing the manuscript. B.D.E. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
The authors thank Laurel Ann Lawrence (Emory University) and Linda Morrison (University of Utah) for managing the mouse colony and screening of mice, Dr. Rustom Antia and Dr. Veronika Zarnitsyna (Emory University) for their expertise and guidance in statistical analysis, Dr. Cheng Zhu and his laboratory (Georgia Institute of Technology), Dr. Joseph Sabatino (Emory University) for technical support and advice with the micropipette adhesion frequency assay, and Hiran Thyagarajan, Mike Faust, Gavile Cathy, and Douglas Cornwall (University of Utah) for careful reading of the manuscript. The authors also thank the National Institutes of Health Tetramer Core Facility (Emory University) for providing all of the pMHC monomers and tetramers used in this study.
No potential conflicts of interest relevant to this article were reported.
Training support from National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (F31-DK-089932) was provided for J.D.H. This work was supported by NIH National Institute of Diabetes and Digestive and Kidney Diseases grant DK-089125 (D.A.V. and M.B.), National Institute of Allergy and Infectious Diseases grant AI-125301 (M.B.), National Institute of Neurological Disorders and Stroke grant NS-071518 (B.D.E.), and American Diabetes Association grant 1-09-IN-16 (B.D.E.).
© 2019 by the American Diabetes Association.