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Author Notes:

Correspondence: Ryan J. Brady, Department of Psychology, Emory University, 36 Eagle Row, Atlanta, GA 30322., ryan.brady@emory.edu

Author contributions: C.F-C., D.M. and J.R.Y. designed the experiments. C.F-C. performed the experiments and acquired the MS data. C.F-C. and S.M.B. analyzed the data. D.M., S.M.B., N.Y. and A.J.S. provided a critical input on the project. C.F-C. wrote the manuscript with input of all authors. J.R.Y conceived and supervised the project.

Acknowledgements: We thank Tara A. Dove-VanWormer for help with testing. We thank Dr. Claire Delahunty for critical reading of the manuscript.

Disclosures: The authors declare no conflicts of interest.

Subjects:

Research Funding:

This work was supported by the National Institute of Health grants 5R01 MH067880 and P41 GM103533.

This project was supported by National Science Foundation grants BCS-1632477, IOS-1146316, BCS-0745573; National Institutes of Health grant RO1MH082819; and by ORIP/OD P51OD011132.

National Institutes of Health, Grant/Award, Number: RO1MH082819;

National Science, Foundation, Grant/Award Numbers: BCS-0745573, BCS-1632477, IOS-1146316; ORIP, Grant/Award Number: OD P51OD011132

Keywords:

  • active encoding
  • hippocampal lesion
  • incidental encoding
  • memory
  • preferential viewing
  • primate
  • Animals
  • Habituation, Psychophysiologic
  • Hippocampus
  • Macaca mulatta
  • Male
  • Photic Stimulation
  • Video Recording

Hippocampal damage attenuates habituation to videos in monkeys

Tools:

Journal Title:

Hippocampus

Volume:

Volume 29, Number 11

Publisher:

, Pages 1121-1126

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Monkeys with selective damage to the hippocampus are often unimpaired in matching-to-sample tests but are reportedly impaired in visual paired comparison. While both tests assess recognition of previously seen images, delayed matching-to-sample may engage active memory maintenance whereas visual paired comparison may not. Passive memory tests that are not rewarded with food and that do not require extensive training may provide more sensitive measures of hippocampal function. To test this hypothesis, we assessed memory in monkeys with hippocampal damage and matched controls by providing them the opportunity to repeatedly view small sets of videos. Monkeys pressed a button to play each video. The same 10 videos were used for six consecutive days, after which 10 new videos were introduced in each of seven cycles of testing. Our measure of memory was the extent to which monkeys habituated with repeated presentations, watching fewer videos per session over time. Monkeys with hippocampal lesions habituated more slowly than did control monkeys, indicating poorer memory for previous viewings. Both groups dishabituated each time new videos were introduced. These results, like those from preferential viewing, suggest that the hippocampus may be especially important for memory of incidentally encoded events.

Copyright information:

© 2019 John Wiley & Sons, Inc. All rights reserved.

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