Hippocampal damage attenuates habituation to videos in monkeys

• Authors: Ryan J. Brady, Emory University; Benjamin M. Basile, National Institute of Mental Health (NIMH); Robert Hampton, Emory University
• Journal Title: Hippocampus
• Volume: Volume 29, Number 11
• Publisher: Wiley | 2019-11-01, Pages 1121-1126
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1002/hipo.23155
• Subjects: Biology, Neuroscience; Psychology, Psychobiology; Biology, Zoology; Health Sciences, Mental Health
• Keywords: active encoding; hippocampal lesion; incidental encoding; memory; preferential viewing; primate; Animals; Habituation, Psychophysiologic; Hippocampus; Macaca mulatta; Male; Photic Stimulation; Video Recording

Abstract

Monkeys with selective damage to the hippocampus are often unimpaired in matching-to-sample tests but are reportedly impaired in visual paired comparison. While both tests assess recognition of previously seen images, delayed matching-to-sample may engage active memory maintenance whereas visual paired comparison may not. Passive memory tests that are not rewarded with food and that do not require extensive training may provide more sensitive measures of hippocampal function. To test this hypothesis, we assessed memory in monkeys with hippocampal damage and matched controls by providing them the opportunity to repeatedly view small sets of videos. Monkeys pressed a button to play each video. The same 10 videos were used for six consecutive days, after which 10 new videos were introduced in each of seven cycles of testing. Our measure of memory was the extent to which monkeys habituated with repeated presentations, watching fewer videos per session over time. Monkeys with hippocampal lesions habituated more slowly than did control monkeys, indicating poorer memory for previous viewings. Both groups dishabituated each time new videos were introduced. These results, like those from preferential viewing, suggest that the hippocampus may be especially important for memory of incidentally encoded events.