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Author Notes:

Jaffar M. Khan, BM, BCh.

Cardiovascular Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

jaffar.khan@nih.gov

Conflicts of Interest: VCB is a consultant for Edwards Lifesciences and for Abbott Vascular, and his employer has research contracts for clinical investigation of transcatheter aortic and mitral devices from Edwards Lifesciences, Abbott Vascular, Medtronic, St Jude Medical, and Boston Scientific. ABG is a proctor for Edwards Lifesciences, Medtronic, and Abbott Vascular. He is a consultant for Transmural Systems. TR is a consultant/proctor for Medtronic and Edwards Lifesciences. He has equity shares in Transmural Systems. RW—Advisory Board: Abbott Vascular, Amgen, Boston Scientific, Medtronic, Philips, Pi-Cardia Ltd., Cardioset; Consultant: Abbott Vascular, Amgen, Biosensors, Biotronik, Boston Scientific, Medtronic, Philips, Pi-Cardia Ltd., Cardioset; Grant Support: Abbott Vascular, AstraZeneca, Biosensors, Biotronik, Boston Scientific, Chiesi; Speakers Bureau: AstraZeneca, Chiesi; Investor: MedAlliance. JMK is a proctor for Edwards Lifesciences and Medtronic. JMK, TR, and RJL are co-inventors on patents, assigned to NIH, on catheter devices to lacerate valve leaflets. NHLBI has a collaborative research and development agreement with Edwards Lifesciences on transcatheter modification of the mitral valve. The other authors have no conflicts of interest to declare.

Subject:

Research Funding:

Supported by the Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, USA (Z01-HL006040).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Cardiac & Cardiovascular Systems
  • Surgery
  • Cardiovascular System & Cardiology
  • Transcatheter mitral valve replacement (TMVR)
  • left ventricular outflow tract obstruction (LVOT obstruction)
  • LAMPOON
  • tip-to-base LAMPOON
  • antegrade LAMPOON
  • LACERATION
  • OUTCOMES
  • LEAFLET
  • REGURGITATION

LAMPOON techniques to prevent or manage left ventricular outflow tract obstruction in transcatheter mitral valve replacement

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Journal Title:

ANNALS OF CARDIOTHORACIC SURGERY

Volume:

Volume 10, Number 1

Publisher:

, Pages 172-179

Type of Work:

Article | Final Publisher PDF

Abstract:

Transcatheter mitral valve replacement (TMVR) is a therapeutic option for patients with severe mitral disease who are deemed inoperable due to their overall surgical risk. The close relationships between the left ventricular outflow tract (LVOT) and the anterior mitral valve leaflet can lead to LVOT obstruction, a common complication with high mortality. Predicting and preventing LVOT obstruction is therefore essential, prior to TMVR. Laceration of the Anterior Mitral leaflet to Prevent Outflow ObtructioN (LAMPOON) is a transcatheter electrosurgical technique to split the anterior mitral valve leaflet immediately prior to TMVR. The technique has been studied in a prospective clinical trial and has evolved with many iterations for specific anatomies. In this review, we discuss the different LAMPOON techniques to prevent and treat LVOT obstruction.

Copyright information:

2021 Annals of Cardiothoracic Surgery.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/rdf).
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