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Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Immunology
  • RESPIRATORY SYNDROME CORONAVIRUS
  • ANTIBODY-RESPONSES
  • MUCOSAL CHALLENGE
  • HIGH-THROUGHPUT
  • IMMUNOGENICITY
  • HIV-1
  • ANTIGEN
  • SPIKE
  • MVA
  • DNA

A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs

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Journal Title:

IMMUNITY

Volume:

Volume 54, Number 3

Publisher:

, Pages 542-+

Type of Work:

Article

Abstract:

Modified vaccinia Ankara (MVA) vector-based vaccines are attractive because of their excellent safety and ability to induce long-lived humoral and cellular immunity in humans. Routhu et al. show that an MVA-based COVID-19 vaccine encoding prefusion-stabilized spike (MVA/S) induces strong neutralizing antibody and CD8+ T cell responses and protects macaques from SARS-CoV2 infection, immunopathology, and infection-induced B cell abnormalities in the lungs.
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