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Author contributions: N.d.l.V.G., R.P., M.N., A.G.d.l.F., Z.L., B.P., R.J.I., and D.C.F. designed research; N.d.l.V.G., R.P., M.D., J.F., J.M., J.R.H., and E.E. performed research; N.d.l.V.G. and M.D. analyzed data; N.d.l.V.G. and D.C.F. wrote the paper; R.P., M.N., A.G.d.l.F., Z.L., B.P., and R.J.I. provided advice on experimental design and interpretation and contributed toward writing the manuscript via suggested edits; M.D., J.R.H., and E.E. contributed toward writing the manuscript via suggested edits; and D.C.F. provided advice on experimental design and interpretation and oversaw the study.
We thank Prof. Anna Williams and her team for kindly providing us with the ImageJ macro used to analyse brain slice images in this study. We thank Anna Magennis for technical support and Rachel Jayne Gillis and Sarah Collis for cell quantification. We also thank QUB Biological Services Unit and the advanced imaging unit staff for their help and advice, particularly Andrena Millar and Dr. Ileana Micu. We thank Dr. Yvonne Dombrowski’s laboratory, Dr. Liza Colhoun, and WWIEM immunology laboratory groups for their advice and guidance through the course of this study.
The authors declare no competing interest.
This work was supported by Biotechnology and Biological Sciences Research Council Grant BB/J01026X/1 (to D.C.F.), Wellcome Trust Grant 110138/Z/15/Z (to D.C.F.), and studentship support from the Department for the Economy (Northern Ireland).
© 2020 the Author(s). Published by PNAS.