gamma-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A

• Authors: Xue Gao, Emory University; Liang Zhao, Emory University; Shuangping Liu, Emory University; Yuancheng Li, Emory University; Siyuan Xia, Emory University; Dong Chen, Emory University; Mei Wang, Emory University; Shaoxiong Wu, Emory University; Qing Dai, University of Chicago; Hieu Vu, University of Texas Southwestern Medical Center, Dallas; Lauren Zacharias, University of Texas Southwestern Medical Center, Dallas; Ralph DeBerardinis, University of Texas Southwestern Medical Center, Dallas; Esther Lim, University of California, San Diego; Christian Metallo, University of California, San Diego; Titus J. Boggon, Yale University; Sagar Lonial, Emory University; Ruiting Lin, Emory University; Hui Mao, Emory University; Yaozhu Pan, Emory University; Changliang Shan, Emory University; Jing Chen, Emory University
• Journal Title: MOLECULAR CELL
• Volume: Volume 76, Number 6
• Publisher: CELL PRESS | 2019-12-19, Pages 857-+
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1016/j.molcel.2019.09.007
• Subjects: Biology, Cell; Chemistry, Biochemistry; Biology, Molecular
• Keywords: Science & Technology; Life Sciences & Biomedicine; Biochemistry & Molecular Biology; Cell Biology; 6-PHOSPHOGLUCONATE DEHYDROGENASE; CELL; PROLIFERATION; ACETYLATION; HOMEOSTASIS; GROWTH; 2A

Abstract

“Dead-end” metabolites in the metabolic reaction network do not have known metabolic functions. In this article, Gao et al. report that γ-6PGL, a byproduct of the oxiPPP, contributes to the Src-PP2A-AMPK signaling pathway by binding to Src and consequently enhancing PP2A recruitment, suggesting that “dead-end” metabolites may function as signaling molecules.