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Author Notes:

rahmed@emory.edu

Conceptualization, W.H.H and R.A.; Methodology, W.H.H. and R.A.; Investigation, W.H.H., J.G., M.H., A.W., R.M.V., B.T.K., and S.J.I.; Resources, P.L., J-X.L., W.J.L., and G.J.F.; Writing - Original Draft, W.H.H. and R.A.; Writing - Review and Editing, W.H.H., J.G., A.W., S.J.I., H.T.K., and R.A.; Visualization, W.H.H.; Supervision, R.A. and H.T.K.; Funding Acquisition, W.H.H. and R.A.

The authors thank Alice Kamphorst, Koichi Araki, Timothy Hoang, and Robert Karaffa and Kametha Fife of the Emory University School of Medicine Flow Cytometry Core.

Rafi Ahmed holds patents on the PD-1 pathway.

Subjects:

Research Funding:

W.H.H. is a Cancer Research Institute Irvington Fellow supported by the Cancer Research Institute. H.T.K. is supported by grant K99CA197804 from the National Cancer Institute of the National Institutes of Health (NIH). R.A. is supported by grants R01AI030048 and P01AI056299 from the National Institute of Allergy and Infectious Diseases of the NIH. The Yerkes Nonhuman Primate Genomics Core is supported in part by ORIP/OD P51OD011132. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Immunology
  • LYMPHOCYTIC CHORIOMENINGITIS VIRUS
  • EXPRESSION
  • GENE
  • DIFFERENTIATION
  • SUBSETS
  • CD101
  • IDENTIFICATION
  • PERSISTENCE
  • EXHAUSTION
  • COOPERATE

Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1(+) Stem-like CD8(+) T Cells during Chronic Infection

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Journal Title:

IMMUNITY

Volume:

Volume 51, Number 6

Publisher:

, Pages 1043-+

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Chronic viral infection induces exhaustion of antigen-specific T cells. Hudson and colleagues define a transitory, effector-like population of CD8+ T cells that are recently generated from stem-like CD8+ T cells in chronic infection. These transitory cells contribute to viral control and are increased in number following PD-1 pathway blockade.

Copyright information:

2019

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/rdf).
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