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Author Notes:

pg2618@cumc.columbia.edu

Conceptualization: P.S.G., G.L.K., M.K.; methodology: P.S.G., G.L.K., M.K.; data recording: G.L.K., V.C.; data analysis, M.K., C.G.S., L.H.; discussion of the results: P.S.G., M.K., G.L.K., T.F., C.G.S., I.H., D.B.R.; writing—original draft preparation, P.S.G., M.K., C.G.S.; writing—review and editing, all authors; supervision, P.S.G., T.F., I.H.; funding acquisition, P.S.G. All authors have read and agreed to the published version of the manuscript.

The authors would like to thank Robert Cohen for his work in developing the rodent model and guidance on their care as well as Qiangguo Xu (Department of Anesthesiology, Emory University) for technical help in biochemical analysis of brain tissue.

The authors declare no conflict of interest.

Subjects:

Research Funding:

This work was in part supported by Departmental Resources (M.K.), the James S. McDonnell Foundation (P.S.G.), NIH Grant NS089719 (D.B.R.), and NIH Grant R01 AG042127 (I.H.).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Physical Sciences
  • Biochemistry & Molecular Biology
  • Chemistry, Multidisciplinary
  • Chemistry
  • Alzheimer&#8217
  • s
  • electroencephalography
  • sleep architecture
  • ALZHEIMERS-DISEASE
  • PERMUTATION ENTROPY
  • GABA(A) RECEPTORS
  • QUANTITATIVE EEG
  • COGNITIVE DECLINE
  • EFFECT SIZE
  • A-BETA
  • GLUTAMATE
  • DEMENTIA
  • AGE

Sleep/Wake Behavior and EEG Signatures of the TgF344-AD Rat Model at the Prodromal Stage

Tools:

Journal Title:

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Volume:

Volume 21, Number 23

Publisher:

, Pages 1-19

Type of Work:

Article | Final Publisher PDF

Abstract:

Transgenic modification of the two most common genes (APPsw, PS1∆E9) related to familial Alzheimer’s disease (AD) in rats has produced a rodent model that develops pathognomonic signs of AD without genetic tau-protein modification. We used 17-month-old AD rats (n = 8) and age-matched controls (AC, n = 7) to evaluate differences in sleep behavior and EEG features during wakefulness (WAKE), non-rapid eye movement sleep (NREM), and rapid eye movement sleep (REM) over 24-h EEG recording (12:12h dark–light cycle). We discovered that AD rats had more sleep–wake transitions and an increased probability of shorter REM and NREM bouts. AD rats also expressed a more uniform distribution of the relative spectral power. Through analysis of information content in the EEG using entropy of difference, AD animals demonstrated less EEG information during WAKE, but more information during NREM. This seems to indicate a limited range of changes in EEG activity that could be caused by an AD-induced change in inhibitory network function as reflected by increased GABAAR-β2 expression but no increase in GAD-67 in AD animals. In conclusion, this transgenic rat model of Alzheimer’s disease demonstrates less obvious EEG features of WAKE during wakefulness and less canonical features of sleep during sleep.

Copyright information:

© 2020 by the authors.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/rdf).
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