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nfsaba@emory.edu (N.F. Saba)
All authors contributed to and approved the manuscript.
The authors thank the patients and their families as well as the clinical study teams for making this study possible.
N. F. S. reports funding for research from Bristol-Myers Squibb and Exelexis, and other from Aduro, Bristol-Myers Squibb, GSK, Lilly, Merck, and Pfizer. G. B. reports grants from Adaptimmune, AstraZeneca, Bayer, Bristol-Myers Squibb, Celgene, Exelixis, Genentech, GlaxoSmithKline, Hoffman-La Roche, Immatics, Immunocore, Incyte, Kite Pharma, Macrogenics, Medimmune, Merck, Novartis, Torque, and Xcovery; and other from AbbVie, Adicet, Amgen, Ariad, AstraZeneca, Bayer, Bristol-Myers Squibb, Celgene, Clovis, Genentech, Hoffman-La Roche, Merck, Novartis, and Xcovery. J. G. reports grants from Bristol-Myers Squibb and Merck KGaA; advisory board fees from AstraZeneca, Bristol-Myers Squibb, Innate Pharma, Nanobiotix, and Merck KGaA; and other from Bristol-Myers Squibb and Merck KGaA. L. Licitra received grants from AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene International, Eisai, Exelixis, Inc., Hoffmann–La Roche Ltd., IRX Therapeutics, MedPace, Inc., Merck Serono, MSD, Novartis, Pfizer, and Roche; honoraria/consultation fees from Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Debiopharm, Doxa Pharma SRL, Eisai, Health & Life SRL, Immuno-Oncology Hub, Incyte Biosciences Italy SRL, Ipsen Innovation, Kura Oncology, Merck Serono, MSD, Nanobiotics SA, Novartis, Roche, and SOBI; and other from Bayer, Bristol-Myers Squibb, Debiopharm, Merck Serono, MSD, and SOBI. J. F. reports grants from AstraZeneca and Bristol-Myers Squibb; honoraria/consultation fees from AstraZeneca, Biogen, Bristol-Myers Squibb, Merck Sharp & Dohme, Merck Serono, Innate Pharma; personal fees from AstraZeneca, Bristol-Myers Squibb, and Merck Sharpe & Dohme. K. J. H. reports grants from AstraZeneca and Merck Sharp & Dohme; personal fees from AstraZeneca, Amgen, Bristol-Myers Squibb, Merck Sharp & Dohme, Merck Serono, and Pfizer. M. L. G. reports grants from AstraZeneca, Bristol-Myers Squibb, Kyowa, and Merck; and personal fees from Amgen, AstraZeneca, Bristol-Myers Squibb, Celgene, GlaxoSmithKline, Lilly, and Merck. R. L. F. reports grants and clinical trial support from AstaZeneca/MedImmune, Bristol-Myers Squibb, Merck, Tesaro, and VentiRx Pharmaceuticals; advisory board/consultation fees from Amgen, AstraZeneca/MedImmune, Bain Capital Life Sciences, Bristol-Myers Squibb, EMD Serono, GlaxoSmithKline, Iovance Biotherapeutics, Inc., Lilly, Merck, Numab Therapeutics AG, Oncorus, Inc., Ono Pharmaceutical Co. Ltd., Pfizer, PPD (Benitec, Immunicum), Regeneron Pharmaceuticals, Inc., Tesaro, Torque Therapeutics Inc., and TTMS. N. K. reports grants from ONO, AstraZeneca, and Pfizer; honoraria from ONO, Bristol-Myers Squibb, Merck Serono, Eisai, and Bayer. L. Li is an employee of and holds stock in Bristol-Myers Squibb. V. J. is an employee of Bristol-Myers Squibb and a former employee of AstraZeneca. All other authors report no conflict of interest.
Writing and editorial assistance was provided by Brooke Middlebrook, BS, of Evidence Scientific Solutions, funded by Bristol-Myers Squibb. K. J. Harrington acknowledges support from the Royal Marsden/the Institute of Cancer Research, National Institute of Health Research Biomedical Research Centre, and Oracle Cancer Trust. R. L. Ferris is supported by the P50 CA097190-14, P30 CA047904-28, and R01 CA206517 grants. The University of Texas MD Anderson Cancer Center is supported by the National Institutes of Health (grant P30 CA016672).
This study was sponsored by Bristol-Myers Squibb (Princeton, NJ, USA) and ONO Pharmaceutical Company, Ltd. (Osaka, Japan).
2019