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The principal investigators, RM Abreu and SK Ono, were responsible for the conception and design of the study, the acquisition, analysis and interpretation of the data, and the drafting of the manuscript. LC Bassit, S Tao, Y Jiang, AS Ferreira, PCA Hori, LM Ganova-Raeva, and Y Khudyakov helped with the design of the study, acquisition of the data, and critical revision of the manuscript regarding intellectual content. RF Schinazi, FJ Carrilho, and SK Ono guided the study and provided input on assays to be performed and helped write and review this paper.
We thank the Alves de Queiroz Family Fund for Research for support of studies, James J. Kohler (Emory University) for manuscript review, Dimitri Gonzalez and Chalom Sayada (Advanced Biological Laboratories – ABL, Luxemburg, Belgium) for the use of DeepChek®–HBVv1.4 software for genotyping and drug resistance analysis. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval for the version to be published. Finally, we greatly thank all patients for their consent and participation in the study and for the research use of their plasma specimens.
A part of this study was presented at the AASLD The Liver Meeting, San Francisco, on 16 Nov, 2015. No commercial funding was involved in this study.
This research was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq number 201812/2014–2 to RMA), (CNPq number 308609/2018–2 and 551407/2007–7 to SKO), SPRINT-Emory FAPESP (2017/50042–2) and in part by NIH sponsored Center for AIDS Research Grant P30AI050409 and 1R01AI132833 (to RFS).
2019